Electric Shock Allows for CRISPR Gene Editing Without a Viral Vector
Ashley Yeager | Jul 12, 2018
Brief electroporation appears to make T cells more receptive to new genetic material, which could speed the development of immunotherapies.
New Ovarian Cancer Vaccine Shows Promise
Catherine Offord | Apr 12, 2018
A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.
High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
New CAR T-Cell Therapy Shows Promise in Trial for Leukemia
Katarina Zimmer | Nov 21, 2017
The immunotherapy, which targets CD22 on cancer cells rather than CD19, might prove useful in patients for whom previous T-cell treatments were unsuccessful.
First CAR T-Cell Therapy Approved in U.S.
Shawna Williams | Aug 30, 2017
The genetically modified blood cells will be used for patients with a type of acute lymphoblastic leukemia, when other treatments fail.
Immunotherapy Promising for Diabetes: Study
Aggie Mika | Aug 9, 2017
A small clinical trial demonstrates that peptide immunotherapy can halt the progression of early-stage type 1 diabetes.
The Ever-Expanding T-Cell World: A Primer
Ashley P. Taylor | Aug 7, 2017
Researchers continue to identify new T-cell subtypes—and devise ways to use them to fight cancer. The Scientist attempts to catalog them all.
T Cells That Drive Toxic Shock in Mice Identified
Ashley Yeager | Jun 20, 2017
Overzealous activity by mucosa-associated invariant T (MAIT) cells in response to bacterial toxins can lead to illness instead of stopping it.
Gene Mutations Foretell Immunotherapy Response
Aggie Mika | Jun 12, 2017
A drug that blocks an immune checkpoint protein effectively treats tumors in patients with deficient DNA repair genes.