translation

Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.

The transcription of DNA drives the remarkably tidy organization of chromosomes in the dinoflagellate Symbiodinium microadriaticum.

The recently discovered long noncoding RNAs seem to boost the production of specific proteins in the cell by interacting with RNA-binding proteins, researchers find.

Aminoacyl tRNA synthetases picked up new protein domains that participate in vasculature formation around the same time that organisms evolved key adaptations in the circulatory system.

Aminoacyl-tRNA synthetases, which help translate the genetic code into protein, also function in angiogenesis, fat metabolism, and more.

Criticism of the paper first surfaced in 1994, and its author was accused of scientific misconduct.

Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.

New research suggests that the cells’ protein factories have preferences for specific messenger RNAs they translate. 

Feeding-fasting rhythms and light-dark cycles direct regular changes in organ and cell size, as well as ribosome number and protein levels.

Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA.
 

Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize.

The year’s most impressive achievements include methods to watch translation in cells, trace cell fates, avoid mitochondrial mutations, edit DNA, and build antibiotics from scratch.

Some ciliates use the same trio of nucleotides to code for an amino acid and to stop translation.

Four independent research groups develop techniques for visualizing peptide production in living cells.

Traditional stop codons have a double meaning in the protozoans' mRNA, sometimes calling for an amino acid during translation.

Newly developed techniques from four different groups rely on the same basic steps to track translation in live cells.

Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.