An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left).
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
ABOVE: eLife, 10:e69199, 2021
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Amyloid Precursor Protein Linked to Brain Development Mechanisms

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

ABOVE: eLife, 10:e69199, 2021

Wnt

Japanese grass pufferfish (Takifugu niphobles) CT scan
Pufferfish Spines Shaped by Same Genes as Feathers and Fish Scales
Nicoletta Lanese | Jul 29, 2019
To see if the spiky fish shares signaling pathways found in other organisms, scientists scooped up specimens during a mating frenzy on the shores of Japan.
Animals’ Embryonic Organizer Now Discovered in Human Cells
Jim Daley | May 23, 2018
The finding confirms that a cluster of cells that directs the fate of other cells in the developing embryo is evolutionarily conserved across the animal kingdom.
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How to Grow a Mouse Embryo in a Dish
Roni Dengler, PhD | Aug 3, 2021
Researchers are taking the concept of three-dimensional cell culture beyond single organoids to develop embryos from cells.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Bouncing Back
Ashley P. Taylor | Feb 1, 2015
In mice, a transcriptional regulator, β-catenin, activates a microRNA-processing pathway in the nucleus accumbens to promote resilience to social stress.
A Hair-Raising Solution?
Dan Cossins | Sep 1, 2013
In the long-fought battle against baldness, researchers are finally identifying molecular pathways that can be manipulated to generate new hair follicles.
Secrets of Re-sprouting Heads
Kate Yandell | Jul 24, 2013
Researchers identify a signaling pathway that can control how well flatworms regenerate the front parts of their bodies.
Fellow Travelers
Dan Cossins | Feb 1, 2013
Collective cell migration relies on a directional signal that comes from the moving cluster, rather than from external cues.
Go Forth, Cells
Dan Cossins | Jan 31, 2013
Watch the cell transplant experiments in zebrafish that suggest certain embryonic cells rely on intrinsic directional cues for collective migration.
The World's Densest Bones
Kirsten Weir | Oct 1, 2006
How a car accident led to an important genetic discovery