Anthrax bacteria (yellow) and a red blood cellWIKIMEDIA, ARTHUR FRIEDLANDERTo create a drug with a lower risk of becoming antibiotic resistant, researchers turned to viruses that naturally infect bacteria, and created a drug that mimics a cell-wall busting viral enzymes called lysins, according to a new report published last week (April 10) in PLOS ONE. Viral lysins appear to resist bacterial evolution that would render them ineffective over time.
“We’ve taken advantage of the evolution of viruses. It’s using nature versus nature,” author Vincent Fischetti head of Rockefeller University’s bacterial pathogenesis and immunology lab told Healthline. “We’ve found it's best when you don’t fight nature. Viruses have been around a lot longer than we have.”
Antibiotic resistance has become an increasing problem in hospitals, rendering a slew of formerly effective antibiotics useless against certain deadly strains of bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). To combat bacteria’s tendency to evolve new methods of bypassing a drug’s mechanism of action, Rockefeller University researchers turned to the viral enzyme lysin that viruses use to break through the bacterial cell wall of a cell they’ve infected as they exit in large numbers. Lysin is particularly resistant to ...
