WIKIMEDIA, NEPHRONThe protein REST, a transcription factor that represses neuron-specific genes during embryogenesis, may be a key regulator of neuronal stress and could help stave off neurodegeneration, researchers from Harvard Medical School reported in Nature this week (March 19). Bruce Yankner and his colleagues identified strong associations between REST and response to neuronal stressors in C. elegans, mice, and humans.
“This work establishes REST as a regulator protein we have to pay a lot of attention to in the context of neurodegeneration,” said Susan Lindquist, a molecular biologist at the MIT Whitehead Institute for Biomedical Research, who was not involved in the work.
WIKIMEDIA, KAIBARA87Stem cells seem to “remember” the surfaces on which they were cultured, according to a study published in Nature Materials on March 16. Scientists from the University of Colorado and their colleagues found that progenitor cells grown on a firm substrate are more likely to differentiate into a bone-cell lineage, whereas cells cultured on softer surfaces are equally likely to become bone or fat cells.
The work “shows some correlations between the stiffness of gels to which these human mesenchymal stem cells were adhered and certain markers of cell commitment,” MIT’s Krystyn Van Vliet, who did not participate in the research, told The Scientist.
WIKIMEDIA, JYNTOThe offspring of pregnant mice raised on a low-vitamin A diet developed smaller lymph nodes than did animals exposed to higher levels of the nutrient in utero, and these animals showed impaired immunity as adults, a team led by researchers at the Instituto de Medicina Molecular in Lisboa, Portugal, showed in Nature this week (March 19).
