FLICKR, NIAIDVaccinating 212 people, including 54 elderly folks, researchers have identified molecular signatures in blood samples that could predict, with 80-percent accuracy, whether the seasonal flu vaccine would elicit significant immune protection. The study, published yesterday (December 15) in Immunity, could pave the way for more-effective vaccines, according to the researchers.
“We provide novel evidence of a potential connection between the baseline state of the immune system in the elderly and reduced responsiveness to vaccination,” coauthors Shankar Subramaniam of the University of California, San Diego, and Bali Pulendran of Emory University said in a press release. “By providing a more complete picture of how the immune system responds to vaccination, our findings may help guide the development of next-generation vaccines that offer long-lasting immunity and better protection of at-risk populations.”
The researchers combined their results on 212 vaccinated individuals with previously published data for 218 subjects, finding that, within a week of vaccination, young people had high levels of B cells, while elderly individuals had high levels of NK cells, as well as of monocytes, which ...
