$18M Grant to Be Re-reviewed

A Texas cancer institute is taking a second look at the largest grant it ever awarded after concerns were raised that the proposal never received proper scientific review.

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Lung cancer cell with irregular bulges in the plasma membrane (purple)FLICKR, WELLCOME IMAGES

In March, the taxpayer-funded Cancer Prevention and Research Institute of Texas (CPRIT) awarded a team of researchers at the Institute for Applied Cancer Science (IACS) at MD Anderson Cancer Center in Houston $18 million to develop new cancer drugs. Last month, the institute’s chief scientific officer, Nobel laureate Alfred Gilman resigned, noting concerns about how the proposal for the large grant—the largest ever awarded by the institute, according to Nature—never underwent scientific review.

Specifically, Gilman suspected that CPRIT had awarded this controversial "incubator" grant, which aims to enhance the existing small molecule lines of research while branching out into biologics, instead of funding seven smaller grants, totaling $39 million, that had already received positive review. And the grant was awarded despite “strikingly lacking in specific[s]” ...

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Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
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