© EVAN OTO/SCIENCE SOURCE
Some 20 percent of cancer-related deaths in the U.S. can be attributed to obesity, making it the number-one preventable cause of cancer death in the country. But with myriad metabolic and inflammatory changes associated with obesity, determining the mechanisms that underlie the obesity-cancer link has proven challenging.
Obesity can increase aromatase expression, resulting in increased estradiol levels, which can promote the growth of estrogen-dependent cancers, including estrogen receptor– positive breast cancers and endometrial cancers.
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