Alzheimer's Drugs Harmful?

The researcher who helped develop an Alzheimer's treatment now in clinical trials warns that the compound may actually impair memory.

Written byBob Grant

| 1 min read

Listen with Speechify

0:00

1:00

WIKIMEDIA COMMONS, THEBRAIN

A new drug aimed at treating Alzheimer's disease (AD) may have deleterious side effects, according to the scientist who discovered the compound's molecular target. Northwestern University cell and molecular biologist Robert Vassar warns that a drug designed to inhibit BACE1, an enzyme that aids in the development of the amyloid plaques that are characteristic of AD, may also stop the enzyme from performing a crucial neuron-mapping function in the brain. Vassar's group cloned and characterized BACE1 in 1999.

Vassar recently showed that mice devoid of BACE1 had olfactory neurons that were improperly wired to the olfactory bulb. This is worrying, Vassar said, because in the hippocampus, as memories are formed, neurons are continually reborn and connections reconfigured, making BACE1's organization role hugely important. Thus, drugs ...

Interested in reading more?

The Scientist ARCHIVES

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!

Join for free today

Already a member? Login Here

Meet the Author

Bob Grant
From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.
View Full Profile