Antibody Spike Months After Ebola Infection Surprisingly Common

A study of people in Sierra Leone suggests that the virus can lie in hiding from the immune system before re-emerging later and sparking a new response—although researchers didn’t examine whether this could make people infectious again.

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ABOVE: An Ebola survivor donates plasma at the blood bank at Connaught Hospital in Freetown, Sierra Leone.
JANET SCOTT

Asubstantial proportion of people who survive Ebola may produce a spike in antibody levels more than six months after they’ve recovered from the disease, according to a study published today (January 27) in Nature.

Analyzing multiple plasma samples from 51 survivors of the West African outbreak of 2013–2016, researchers found that the levels of virus-neutralizing antibodies declined, as expected, in the days and weeks following recovery. But these levels shot up again in some survivors around the 200- to 300-day mark before declining again—evidence that Ebola virus may be lingering inside their bodies and re-emerging to trigger immune defenses, the researchers conclude in their paper.

“The idea that there can be a source of virus that could restimulate the immune system isn’t surprising” in itself, says Carl Davis, an immunologist at Emory ...

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Meet the Author

  • Catherine Offord

    Catherine is a science journalist based in Barcelona.
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