Blood’s Role in the Aging Brain

A blood protein involved in allergy contributes to the decline in brain function and memory in aging mice.

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WIKIMEDIA COMMONS, ADAM JONES, ADAMJONES.FREEZERVERS.COM

A blood-borne immune factor present in elderly mice contributes to signs of mental decline when injected into young mice, and inhibiting it restores youthfulness in old mice, according to an article published online today (August 31) in Nature. The study implies that it may be possible to change some of the symptoms of aging in the brain by altering the levels of immune factors in the blood.

"This is a really phenomenal, complete study," Sally Temple, a developmental neuroscientist and scientific director of the New York Neural Stem Cell Institute, who was not involved in the research, wrote in an email. "These experiments were particularly convincing because they addressed the issues at multiple levels, from proteomics analysis, to electrophysiology, to mouse behavior, and the authors ...

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