Broken Heart Syndrome Linked to the Brain

A chronically stressed amygdala can prime the heart to overreact to acute stress events, a new study shows.

amanda heidt
| 4 min read

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ABOVE: Takotsubo syndrome is so named because it causes the heart’s left ventricle to weaken (left) so that the organ assumes a shape reminiscent of the Tako-Tsubo pot used in Japan to catch octopuses (right).
EUR HEART J, DOI:10.1093/EURHEARTJ/EHAB029, 2021; THE SCIENTIST STAFF

The paper
A. Radfar et al., “Stress-associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome,” Eur Heart J, ehab029, 2021

Takotsubo syndrome, also known as broken heart syndrome, is a rare, reversible condition with symptoms mimicking a mild heart attack. A disease that disproportionately affects women, TTS is triggered by stressful events such as bankruptcy, the death of a loved one, or divorce, and results in a weakening of the heart’s left ventricle such that it becomes temporarily misshapen.

Previous work has shown that TTS patients have elevated activity in their amygdala, a brain region involved in stress response. What has never been ...

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Meet the Author

  • amanda heidt

    Amanda Heidt

    Amanda was an associate editor at The Scientist, where she oversaw the Scientist to Watch, Foundations, and Short Lit columns. When not editing, she produced original reporting for the magazine and website. Amanda has a master's in marine science from Moss Landing Marine Laboratories and a master's in science communication from UC Santa Cruz.

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