Caution Urged for Comparing Ancient and Modern Humans’ Oral Microbes

Microbial species that are commonly associated with oral diseases in modern humans are unreliable proxies for determining tooth health status in ancient samples, a new study finds.

Written byAlejandra Manjarrez, PhD
| 4 min read
oral microbe dental plaque calculus ancient hominin skeleton teeth

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

ABOVE: For this study, the researchers analyzed teeth from dozens of skeletal remains, including this jaw, which belonged to a young man who lived roughly 200 years ago. Several teeth have extensive calculus covering the tooth crown.
IRINA M. VELSKO

By scraping the teeth of our ancestors and looking at the microbes on them, scientists have sought to reconstruct the lives of ancient hominins, in particular, what type of diseases they faced. But a recent study challenges one of the assumptions in the field: that we can use our knowledge about modern humans’ dental plaque—the sticky biofilm attached to tooth surfaces—to understand its mineralized version, known as dental calculus, frequently found in human fossils.

The results, published July 6 in Microbiome, show that the microbial profiles of plaque and calculus are different, mainly due to the maturation stage of the biofilm found in each substrate, and using remains’ calculus to infer ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

    View Full Profile
Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

Thermo Fisher Logo
Discover how to streamline tumor-infiltrating lymphocyte production.

Producing Tumor-infiltrating Lymphocyte Therapeutics

cytiva logo

Products

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery