Cell and Gene Therapy Tracker: Global CAR T-Cell Trials

Investigators have launched numerous clinical trials that test the efficacy of the immunotherapy. Here is a global accounting of these experiments.

Written byThe Scientist
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With our partners at CellTrials.org, we've developed an interactive map that displays the numbers of CAR T-cell trials taking place in countries across the world. Trials are categorized as targeting either hematologic malignancies or solid tumors. Click a country on the map to access the data on trials occurring there or scroll through the list of countries using the arrows to the left or right of the country name.

Researchers developed the first chimeric antigen receptor T cells, modified immune cells that can recognize tough-to-target cancer antigens, about three decades ago. In the past 20 years, scientists have tweaked CAR-T cells to become potent weapons against tumors. These efforts have been rewarded with several recent approvals by the US Food and Drug Administration (FDA). Last year, the FDA approved the first CAR T-cell therapy, Kymriah, which was developed by pharmaceutical giant Novartis and uses modified patient immune cells to target ...

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