Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study

The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.

The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.

cell therapy
Gene Editing Makes Cells Evade Immune Attack In Vitro
Gene Editing Makes Cells Evade Immune Attack In Vitro
Emma Yasinski | Dec 12, 2019
To advance the possibility of off-the-shelf cardiac cell therapies, scientists devise an engineered cardiac stem cell that avoids stimulating a detrimental immune attack.
Neural Stem Cell Transplantation Crawls Toward the Clinic
Neural Stem Cell Transplantation Crawls Toward the Clinic
Ashley P. Taylor | Oct 29, 2019
Several early-stage clinical trials indicate that implanting patients with the cells is safe. But whether they can alleviate neurological problems remains to be seen.
Judge Says FDA Can Stop Clinic from Selling Stem Cell Treatments
Judge Says FDA Can Stop Clinic from Selling Stem Cell Treatments
Emma Yasinski | Jun 7, 2019
The decision may facilitate the agency cracking down more effectively on the unproven interventions these companies sell.
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
John D. Loike, Martin Grumet | Mar 7, 2019
Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully.
The Biggest Science News of 2018
The Biggest Science News of 2018
Kerry Grens | Dec 27, 2018
From disastrous scientific setbacks to the upending of scientific dogma and the end of a 40-year search for a protein
Journals Retract 13 Papers from Heart Stem Cell Lab
Journals Retract 13 Papers from Heart Stem Cell Lab
Kerry Grens | Dec 14, 2018
It’s the latest fallout from an investigation by Harvard and Brigham and Women’s into work overseen by Piero Anversa.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Ashley P. Taylor | Nov 14, 2018
This is the first time researchers have tested the use of the reprogrammed stem cells in the human brain.
Heart Cell Therapy Trial Paused After Fraud Allegations
Heart Cell Therapy Trial Paused After Fraud Allegations
Ashley P. Taylor | Oct 30, 2018
A trial to test whether so-called c-kit cardiac stem cells, first reported by Piero Anversa, could help patients with chronic heart failure has been halted in light of suspicion surrounding his work.