Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.

immunotherapy
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Kerry Grens | Jan 20, 2020
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Immunology Leader Vincenzo Cerundolo Dies
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
CAR T Immunotherapy May Find New Use in Treating Cardiac Fibrosis
CAR T Immunotherapy May Find New Use in Treating Cardiac Fibrosis
Emma Yasinski | Sep 11, 2019
Scientists show the approach can kill cells that cause hardening of heart tissue in mice.
Northwestern University Stem Cell Therapy Clinic Closes Abruptly
Northwestern University Stem Cell Therapy Clinic Closes Abruptly
Katarina Zimmer | Sep 6, 2019
A Chicago-based center that has long operated a clinical trial program for stem cell therapies, has stopped recruiting further patients as its chief, Richard Burt, leaves for a research sabbatical.
In Situ Vaccination: A Cancer Treatment a Century in the Making
In Situ Vaccination: A Cancer Treatment a Century in the Making
Emma Yasinski | Jul 25, 2019
Injecting immunostimulants directly into the tumor is not a new strategy to stimulate the immune system, but the approach has seen a surge of interest in recent years.
T Cell Proliferation Linked to CAR T Responses
T Cell Proliferation Linked to CAR T Responses
Ashley Yeager | Jul 15, 2019
Comparing the cells of cancer patients who did and did not respond to the immunotherapy could reveal biomarkers to predict who should receive it in the first place.
Does the Microbiome Help the Body Fight Cancer?
Does the Microbiome Help the Body Fight Cancer?
Catherine Offord | Jul 10, 2019
Research in mice and humans is beginning to establish a link between the composition of microbes in the gut and immune responses to tumor cells, but the mechanisms are not yet clear.
Clinical Trial Underway for a Natural Killer Cell Therapy
Clinical Trial Underway for a Natural Killer Cell Therapy
Chia-Yi Hou | May 7, 2019
The cells, derived from induced pluripotent stem cells, are in testing as an immunotherapy for cancer patients with solid tumors.
Peanut Allergy Immunotherapy Increases Anaphylaxis Risk: Study
Peanut Allergy Immunotherapy Increases Anaphylaxis Risk: Study
Kerry Grens | Apr 26, 2019
Although the oral treatment seems to work, an analysis of the results from 12 clinical trials finds kids who got an immunotherapy have a greater rate of serious reactions.