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Artist’s rendering of various orange and pink colored bacteria
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?
The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?

The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.

The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.

immunotherapy
An artist’s rendition of transcription inside a nucleus
Hypertranscription by Tumors Is Linked to Poorer Cancer Outcomes: Study
Sophie Fessl, PhD | Dec 13, 2022 | 3 min read
The extent to which transcription is higher in tumor cells than in surrounding nontumor cells is associated with bad prognoses in several cancer types.
Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.<br><br>
Immunotherapy Treats Fibrosis in Mice
Alejandra Manjarrez, PhD | Sep 15, 2022 | 4 min read
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
Single Cell and Spatial Imaging of the Tumor Microenvironment
A Guide to Mapping the Complexity of the Tumor Microenvironment
The Scientist’s Creative Services Team | 1 min read
High-quality sample preparation, single-cell analysis, and ultra-high content spatial proteomics for multi-dimensional research workflows.
illustration of blue cells with exosomes budding off of them and floating away
Nanoparticles Spur Mouse Immune System to Attack Cancer
Shafaq Zia | Sep 13, 2022 | 2 min read
A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022 | 3 min read
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Sartorius
Understanding the Blood Cancer Genomic Landscape 
The Scientist’s Creative Services Team | 1 min read
Information about the genomic and immunological characteristics of blood cancers is helping scientists discover and develop new immunotherapies.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022 | 1 min read
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022 | 4 min read
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Discover how counterflow centrifugation streamlines cell therapy workflows
Closed Cell Processing Systems for Cell Therapy Workflows
Thermo Fisher Scientific | 1 min read
Closed systems increase cell therapy manufacturing process efficiency.
Artist's rendition of a yellow CAR T cell near a red cancer cell surrounded by red blood cells.
Ten Years On, CAR T Cell Recipient Is Still Cancer-Free
Jef Akst | Feb 3, 2022 | 2 min read
First, the genetically engineered cells became CD8+ killer T cells that wiped out his leukemia. Then they transformed into a stable population of CD4+ helper T cells that continue to circulate in his body.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa, PhD | Feb 3, 2022 | 5 min read
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
Breaking Down Barriers: Cell Therapy for Solid Tumors
The Persistence of (T Cell) Memory: Towards Cellular Therapy for Solid Tumors
The Scientist’s Creative Services Team | 1 min read
In this webinar, Douglas Green will describe how early events in T cell activation influence anti-tumor immunity. 
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
Illustration of clear cells with orange nuclei, Toxoplasma gondii, on colorful background
Turning Toxoplasma Against Cancer
Annie Melchor | Jan 3, 2022 | 9 min read
Several research groups have found that Toxoplasma gondii infection can ramp up antitumor immune responses in mice. Can the single-cell parasite be used to develop safe treatments for humans?
Explore the importance of cellular diversity in health and disease through single cell resolution.
Single Cell Resolution Reveals Cellular Diversity
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
Access to single cell resolution reveals new insights into how the human body and its cells operate during health and disease.
fingertips with pills on them
Over-the-Counter Antihistamines Could Help Against Cancer
Alejandra Manjarrez, PhD | Nov 24, 2021 | 3 min read
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
A false-colored micrograph showing swirls of yellow, red, and magenta cells
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl, PhD | Jul 16, 2021 | 6 min read
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Learn How the Immune System Can Be Trained to Overcome Food Allergies
Retraining the Immune System Cavalry for Food Allergen Peacekeeping Missions
The Scientist’s Creative Services Team | 1 min read
Explore food allergy immunotherapy for reversing patient symptoms.
Updated
blue and white sign for the entrance to the FDA that says U.S. Department of Health and Human Services Food and Drug Administration
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021 | 2 min read
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
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