Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

immunotherapy
Updated
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena | Mar 5, 2021
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
Fecal Transplant Could Boost Immunotherapy to Treat Melanoma
Fecal Transplant Could Boost Immunotherapy to Treat Melanoma
Shawna Williams | Feb 12, 2021
The results from two Phase 1 trials bolster the case that the gut microbiome plays a role in response to the drugs.
Infographic: How Immunotherapy Could Boost Stem-Like T Cells
Infographic: How Immunotherapy Could Boost Stem-Like T Cells
Daniel E. Speiser and Werner Held | Jul 13, 2020
Cancer therapies could potentially be more effective if their development took into account the cells that give rise to tumor-fighting cells.
Contributors
Contributors
The Scientist Staff | Jul 13, 2020
Meet some of the people featured in the July/August 2020 issue of The Scientist.
Harnessing Stem Cell–Like T Cells to Better Fight Cancer
Harnessing Stem Cell–Like T Cells to Better Fight Cancer
Daniel E. Speiser and Werner Held | Jul 13, 2020
Better understanding the CD8+ T cells already present in tumors could be key to making immunotherapies work for more patients.
Natural Killer Cell Therapies Catch Up to CAR T
Natural Killer Cell Therapies Catch Up to CAR T
Bianca Nogrady | Apr 1, 2020
There’s a new cell-based cancer immunotherapy on the block.
Flu Shot Ignites Immune Attack Against Cancer in Mice
Flu Shot Ignites Immune Attack Against Cancer in Mice
Ashley Yeager | Apr 1, 2020
Injecting the seasonal flu vaccine directly into clumps of malignant cells recruits immune cells to confront the cancer.
CAR T Cell Adds Scorpion Venom to Tackle Tumor Heterogeneity
CAR T Cell Adds Scorpion Venom to Tackle Tumor Heterogeneity
Amy Schleunes | Mar 24, 2020
A newly engineered CAR T cell that incorporates a peptide isolated from the venom of the deathstalker scorpion has broad brain tumor–binding capabilities that will be investigated in an upcoming clinical trial.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Catherine Offord | Jan 24, 2020
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Kerry Grens | Jan 20, 2020
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Immunology Leader Vincenzo Cerundolo Dies
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.