Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.
Immunotherapy Treats Fibrosis in Mice
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
Immunotherapy Treats Fibrosis in Mice
Immunotherapy Treats Fibrosis in Mice

Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.

Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.

immunotherapy
illustration of blue cells with exosomes budding off of them and floating away
Nanoparticles Spur Mouse Immune System to Attack Cancer
Shafaq Zia | Sep 13, 2022
A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Explore the importance of cellular diversity in health and disease through single cell resolution.
Single Cell Resolution Reveals Cellular Diversity
The Scientist Creative Services Team and 10x Genomics
Access to single cell resolution reveals new insights into how the human body and its cells operate during health and disease.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Learn How the Immune System Can Be Trained to Overcome Food Allergies
Retraining the Immune System Cavalry for Food Allergen Peacekeeping Missions
The Scientist Creative Services Team
Explore food allergy immunotherapy for reversing patient symptoms.
Artist's rendition of a yellow CAR T cell near a red cancer cell surrounded by red blood cells.
Ten Years On, CAR T Cell Recipient Is Still Cancer-Free
Jef Akst | Feb 3, 2022
First, the genetically engineered cells became CD8+ killer T cells that wiped out his leukemia. Then they transformed into a stable population of CD4+ helper T cells that continue to circulate in his body.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa | Feb 3, 2022
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
 Learn how genetics research identifies new targets for complex disease therapies.
Revealing Gene Functions in Health and Disease
The Scientist Creative Services Team and Fortis Life Sciences
Understanding genetic mechanisms that alter cellular pathways.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl | Jan 6, 2022
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
Illustration of clear cells with orange nuclei, Toxoplasma gondii, on colorful background
Turning Toxoplasma Against Cancer
Annie Melchor | Jan 3, 2022
Several research groups have found that Toxoplasma gondii infection can ramp up antitumor immune responses in mice. Can the single-cell parasite be used to develop safe treatments for humans?
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
fingertips with pills on them
Over-the-Counter Antihistamines Could Help Against Cancer
Alejandra Manjarrez | Nov 24, 2021
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
A false-colored micrograph showing swirls of yellow, red, and magenta cells
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl | Jul 16, 2021
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
3-D image of a tumor
Cancer Cells Go Incognito to Cause Therapy Relapse
Niki Spahich, PhD
Dormant cancer cells and dysfunctional immune cells living together in a tumor niche form a therapy-resistant reservoir.
Updated
blue and white sign for the entrance to the FDA that says U.S. Department of Health and Human Services Food and Drug Administration
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
A microscopy image of a mouse brain that shows the lymphatic system in bright purple and pink
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Discover how counterflow centrifugation streamlines cell therapy workflows
Closed Cell Processing Systems for Cell Therapy Workflows
The Scientist Creative Services Team and Thermo Fisher Scientific
Closed systems increase cell therapy manufacturing process efficiency.
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena | Mar 5, 2021
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.