ADVERTISEMENT
3D illustration of a lymphocyte in white and green.
A Quest for the Holy Grail of Cancer Targets
Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.
A Quest for the Holy Grail of Cancer Targets
A Quest for the Holy Grail of Cancer Targets

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

cancer immunotherapy

3D rendered image showing enhanced scanning electron micrograph of cancer cells.
Turning Off Metastasis in Breast Cancer
Nathan Ni, PhD | Feb 13, 2024 | 4 min read
An on-off enzyme switch controls metastasis in mice. 
A Master Regulator of Gene Expression
Mariella Bodemeier Loayza Careaga, PhD | Jan 31, 2024 | 4 min read
A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells. 
Sino Biological 
CAR Technology in Cancer Therapy: From CAR-T to CAR-NK
The Scientist and Sino Biological | 4 min read
From early target discovery to preclinical development stages, researchers explore novel strategies for effective cell therapies in cancer treatment.
3D rendered medical illustration of T cells trying to subdue cancer cells.
How Tumors Tire Out T Cells
Bruker Cellular Analysis | Jul 19, 2023 | 1 min read
Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.
Artist’s rendering of various orange and pink colored bacteria
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?
Dan Robitzski | Feb 3, 2023 | 10+ min read
The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.
3D rendered image of multiple antibody-drug conjugate next generation antibodies.
Advances in Antibody Therapeutics
Elina Kadriu | 4 min read
Scientists engineer therapeutic antibodies with improved stability and efficacy. 
An artist’s rendition of transcription inside a nucleus
Hypertranscription by Tumors Is Linked to Poorer Cancer Outcomes: Study
Sophie Fessl, PhD | Dec 13, 2022 | 3 min read
The extent to which transcription is higher in tumor cells than in surrounding nontumor cells is associated with bad prognoses in several cancer types.
illustration of blue cells with exosomes budding off of them and floating away
Nanoparticles Spur Mouse Immune System to Attack Cancer
Shafaq Zia | Sep 13, 2022 | 2 min read
A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  
Proteomics: Pushing Towards Single-Cell Resolution
Proteomics: Pushing Towards Single-Cell Resolution
The Scientist | 1 min read
Learn how the latest single-cell proteomics technology is revolutionizing protein analysis and driving research progress.
3-D image of a tumor
Cancer Cells Go Incognito to Cause Therapy Relapse
Niki Spahich, PhD | Jun 27, 2022 | 3 min read
Dormant cancer cells and dysfunctional immune cells living together in a tumor niche form a therapy-resistant reservoir.
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022 | 3 min read
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Fortis Life Sciences | 3 min read
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022 | 1 min read
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022 | 3 min read
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Boosting CAR T Cell Therapy for Solid Tumors
The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read
Katie McKenna will discuss how oncolytic viral therapy enhances CAR-T cell killing of cancer cells.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa, PhD | Feb 3, 2022 | 5 min read
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
The Scientist Speaks Podcast - Episode 10
The Scientist | 1 min read
Cancer Immunotherapy: CRISPR Reveals Targets In Vivo
Illustration of clear cells with orange nuclei, Toxoplasma gondii, on colorful background
Turning Toxoplasma Against Cancer
Annie Melchor | Jan 3, 2022 | 9 min read
Several research groups have found that Toxoplasma gondii infection can ramp up antitumor immune responses in mice. Can the single-cell parasite be used to develop safe treatments for humans?
ADVERTISEMENT