cancer immunotherapy

Administering immunotherapy when the tumor microenvironment is most susceptible to T cells enhances treatment efficacy in mice.

Learn how immunotherapy is revolutionizing autoimmune disorder treatment.

A new study finds an unexpected role for hepatocytes in anticancer immunity.

Superior quality cytokines are crucial for reliable research results and the safe production of cancer cell therapies.

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

An on-off enzyme switch controls metastasis in mice. 

A CRISPR-based screening platform helped scientists identify a transcription factor that makes CAR T cells better at killing cancer cells. 

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

From early target discovery to preclinical development stages, researchers explore novel strategies for effective cell therapies in cancer treatment.

Scientists engineer therapeutic antibodies with improved stability and efficacy. 

The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.

The extent to which transcription is higher in tumor cells than in surrounding nontumor cells is associated with bad prognoses in several cancer types.

Learn how the latest single-cell proteomics technology is revolutionizing protein analysis and driving research progress.

Researchers reduce therapeutic CAR T cell heterogeneity with targeted single-cell transcriptomics.

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

Dormant cancer cells and dysfunctional immune cells living together in a tumor niche form a therapy-resistant reservoir.

Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.