Could Brain Activity During Sleep Be a Biomarker for Alzheimer’s?

Changes in brain waves while snoozing correlate with accumulation of tau and amyloid-β, suggesting that the neural activity disruptions could clue doctors in to early development of the disease.

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The paper
J.R. Winer et al., “Sleep as a potential biomarker of tau and β-amyloid burden in the human brain,” J Neurosci, 39:6315–24, 2019.

Everybody sleeps, but not all sleep is created equal. Good sleep appears to keep the brain healthy, clearing toxins from the organ. But bad sleep might be a sign of neurodegenerative disease, with past studies linking sleep disturbances to the progression of Alzheimer’s disease.

Interested in whether brain waves correlated to accumulation of tau and amyloid-β, two proteins considered hallmarks of the disease, University of California, Berkeley, graduate student Joseph Winer and colleagues took positron emission tomography measures of the proteins in 31 cognitively healthy individuals in their 70s, then gathered electroencephalogram (EEG) readings of brain activity patterns while the participants slept.

Analyzing the data, the team found that the degree of synchronization of two types of brain waves prominent during sleep—bursts ...

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Meet the Author

  • Ashley Yeager

    Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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