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Artist’s rendition of a neuron silhouetted against a glowing red background.
SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s
Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.
SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s
SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s

Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.

Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.

neurodegenerative diseases
A collection of images from previous neuroscience articles, including those of an octopus in a chamber, artistic renditions of a brain, brain scans, and an image of neural connections in vitro.
Our Favorite Neuroscience Stories of 2022
Dan Robitzski | Dec 28, 2022 | 4 min read
This year, neuroscience researchers made important discoveries related to how neurodegeneration attacks the human brain, hooked cultured neurons up to machinery to teach them to play a video game, and more.
Microglia stained black
Opinion: Harnessing Microglia Cells to Stave Off Neurodegeneration
Kristine Zengeler, The Conversation | Dec 8, 2022 | 5 min read
Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.
Discover the potential of AAV vectors for gene therapy delivery
From Concept to Cure: Using AAV in Gene Therapy
The Scientist’s Creative Services Team and Bio-Rad Laboratories | 1 min read
With the right tools and techniques, researchers develop safe and effective adeno-associated virus (AAV)-based gene therapies.
Photo of Chantell Evans
Chantell Evans Tracks Mitochondrial Cleanup in Neurons
Holly Barker | Dec 1, 2022 | 3 min read
The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.
Illustration of myelinated neuron axons in light blue, with spindly blue and purple cells interspersed among them.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
Andy Carstens | Nov 22, 2022 | 5 min read
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.
Motor neurons, undergoing degeneration in ALS
Mutant T Cells That Drive Amyotrophic Lateral Sclerosis (ALS) Progression May React To a Brain Antigen
Nele Haelterman, PhD | 4 min read
Scientists discovered a possibly autoreactive T cell population that forecasts and supports disease progression.
A false color transmission electron microscope micrograph showing the nuclear envelope, the rough endoplasmic reticulum, the nucleus, and the cytoplasm.
New Gene Mutants Identified in Rare Motor Neuron Diseases
Clare Watson | Oct 17, 2022 | 2 min read
The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
A Rising Star Launches Brain Power into Outer Space
Science Philosophy in a Flash - A Rising Star Launches Brain Power into Outer Space
Iris Kulbatski, PhD | 1 min read
Alysson Muotri shares how tapping into his inner creative spark fuels his pursuit of science.
Photo of Ankara Jain in his lab
Ankur Jain Explores RNA Aggregations in Neurodegenerative Disease
Hannah Thomasy | Oct 3, 2022 | 3 min read
The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.
A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Amanda Heidt | Sep 22, 2022 | 2 min read
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
Explore how scientists determine the atomic structures of protein aggregates
Revolutionizing Neurodegeneration Research with Cryo-EM
The Scientist’s Creative Services Team and Thermo Fisher Scientific | 1 min read
Advancements in cryo-EM technology allow researchers to develop drugs and diagnostic tools for neurodegenerative diseases.
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022 | 3 min read
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
Cartoon of a silhouetted person’s bright pink brain being shocked by jumper cables
Electrically Zapping Specific Brain Regions Can Boost Memory
Dan Robitzski | Aug 22, 2022 | 3 min read
Low-intensity electrical stimulation allows older adults to better recall a list of words for at least a month following the treatment, a study finds, providing further evidence for the debated idea that electrical stimulation can enhance cognitive performance.
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease
The Scientist Speaks - Lipids Predict a Slippery Path Towards Parkinson’s Disease
Nele Haelterman, PhD | 1 min read
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease.
Infographic showing how neurodegenerative diseases have long been associated with aggregations of apparently toxic proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Catherine Offord | Aug 1, 2022 | 5 min read
Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.
Amyloid plaques on axons of neurons
The Misunderstood Proteins of Neurodegeneration
Catherine Offord | Aug 1, 2022 | 10+ min read
The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
40422-lt-highqualityscreening-800x560
High-Quality Screening and Target Validation During Drug Development
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific | 1 min read
Drew Adams will discuss his work developing therapeutics that promote remyelination for neurological diseases.
3D illustration showing neurons inside the brain
Experimental Pill to Treat Parkinson’s Is Safe, Trial Finds
Andy Carstens | Jun 10, 2022 | 2 min read
Testing in animals and lab-grown cells suggests the experimental drug could enhance the function of lysosomes within cells.
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