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Cropped view of senior man playing with puzzles
A Rare Genetic Mutation Protects Against Alzheimer's Disease
Data from a highly resilient individual guided researchers to new potential therapeutic targets.
A Rare Genetic Mutation Protects Against Alzheimer's Disease
A Rare Genetic Mutation Protects Against Alzheimer's Disease

Data from a highly resilient individual guided researchers to new potential therapeutic targets.

Data from a highly resilient individual guided researchers to new potential therapeutic targets.

neurodegenerative diseases

Chiara Zurzolo and Ranabir Chakraborty stand next to a computer monitor displaying a microscopy image
Microglia Rescue Aggregate-Burdened Neurons
Charlene Lancaster, PhD | Jun 12, 2023 | 4 min read
Researchers discover that neurons trade protein aggregates for microglial-derived mitochondria through tunneling nanotubes. 
a mouse moves away from the camera, its left leg caught in a cloth
Scientists Discover New “Superfast” Muscle Fibers in Mouse Limbs
Katherine Irving | Feb 9, 2023 | 4 min read
Fast twitch fibers like these could one day be used to treat diseases like Parkinson’s.
Abstract blue brain image
Integrating Technologies into Neurodegenerative Disease Research
Thermo Fisher Scientific | 1 min read
Genetic analysis techniques give researchers the power to better understand, detect, and treat disease.
Artist’s rendition of a neuron silhouetted against a glowing red background.
SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s
Dan Robitzski | Jan 6, 2023 | 4 min read
Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.
A collection of images from previous neuroscience articles, including those of an octopus in a chamber, artistic renditions of a brain, brain scans, and an image of neural connections in vitro.
Our Favorite Neuroscience Stories of 2022
Dan Robitzski | Dec 28, 2022 | 4 min read
This year, neuroscience researchers made important discoveries related to how neurodegeneration attacks the human brain, hooked cultured neurons up to machinery to teach them to play a video game, and more.
Discover the potential of AAV vectors for gene therapy delivery
From Concept to Cure: Using AAV in Gene Therapy
The Scientist’s Creative Services Team and Bio-Rad Laboratories | 1 min read
With the right tools and techniques, researchers develop safe and effective adeno-associated virus (AAV)-based gene therapies.
Microglia stained black
Opinion: Harnessing Microglia Cells to Stave Off Neurodegeneration
Kristine Zengeler, The Conversation | Dec 8, 2022 | 5 min read
Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.
Photo of Chantell Evans
Chantell Evans Tracks Mitochondrial Cleanup in Neurons
Holly Barker, PhD | Dec 1, 2022 | 3 min read
The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.
A Rising Star Launches Brain Power into Outer Space
Science Philosophy in a Flash - A Rising Star Launches Brain Power into Outer Space
Iris Kulbatski, PhD | 1 min read
Alysson Muotri shares how tapping into his inner creative spark fuels his pursuit of science.
Illustration of myelinated neuron axons in light blue, with spindly blue and purple cells interspersed among them.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
Andy Carstens | Nov 22, 2022 | 5 min read
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.
A false color transmission electron microscope micrograph showing the nuclear envelope, the rough endoplasmic reticulum, the nucleus, and the cytoplasm.
New Gene Mutants Identified in Rare Motor Neuron Diseases
Clare Watson | Oct 17, 2022 | 2 min read
The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.
Explore how scientists determine the atomic structures of protein aggregates
Revolutionizing Neurodegeneration Research with Cryo-EM
The Scientist’s Creative Services Team and Thermo Fisher Scientific | 1 min read
Advancements in cryo-EM technology allow researchers to develop drugs and diagnostic tools for neurodegenerative diseases.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Photo of Ankara Jain in his lab
Ankur Jain Explores RNA Aggregations in Neurodegenerative Disease
Hannah Thomasy, PhD, Drug Discovery News | Oct 3, 2022 | 3 min read
The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease
The Scientist Speaks - Lipids Predict a Slippery Path Towards Parkinson’s Disease
Nele Haelterman, PhD | 1 min read
Melissa Vos discusses how lipids’ good intentions become harmful in Parkinson’s Disease.
A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Amanda Heidt | Sep 22, 2022 | 2 min read
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022 | 3 min read
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
40422-lt-highqualityscreening-800x560
High-Quality Screening and Target Validation During Drug Development
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific | 1 min read
Drew Adams will discuss his work developing therapeutics that promote remyelination for neurological diseases.
Cartoon of a silhouetted person’s bright pink brain being shocked by jumper cables
Electrically Zapping Specific Brain Regions Can Boost Memory
Dan Robitzski | Aug 22, 2022 | 3 min read
Low-intensity electrical stimulation allows older adults to better recall a list of words for at least a month following the treatment, a study finds, providing further evidence for the debated idea that electrical stimulation can enhance cognitive performance.
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