Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

neurodegenerative diseases
Infographic: Modeling Neurodegenerative Diseases with Yeast
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
Contributors
Contributors
The Scientist Staff | Oct 1, 2021
Meet some of the people featured in the October 2021 issue of The Scientist.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Emma Yasinski | Aug 24, 2021
Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.
Biogen Defends Newly Approved Alzheimer’s Drug
Biogen Defends Newly Approved Alzheimer’s Drug
Jef Akst | Jul 27, 2021
The US Food and Drug Administration has called for a federal investigation of its own regulatory review process after widespread criticism of its decision on Aduhelm.
Questions Raised About Widely Used Blood-Brain Barrier Model
Questions Raised About Widely Used Blood-Brain Barrier Model
Catherine Offord | Feb 16, 2021
A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
New Drug Combo for ALS Slows Decline in Small Clinical Study
New Drug Combo for ALS Slows Decline in Small Clinical Study
Jef Akst | Sep 3, 2020
After six months, patients with fast-progressing amyotrophic lateral sclerosis who had received the experimental treatment had less loss of function than those who received a placebo.
Flu and Pneumonia Vaccines Linked to Reduced Risk of Alzheimer’s
Flu and Pneumonia Vaccines Linked to Reduced Risk of Alzheimer’s
Amanda Heidt | Jul 27, 2020
The authors propose that the shots might keep the immune system primed to battle diseases that would otherwise contribute to cognitive decline.
Astrocyte-to-Neuron Method Reverses Neurodegeneration in Mice
Astrocyte-to-Neuron Method Reverses Neurodegeneration in Mice
Ruth Williams | Jun 24, 2020
The cell conversion strategy restores neurons and motor functions lost as a result of an induced Parkinson’s-like illness in the animals.
Variants in Water Channel Gene Tied to More Restful Sleep
Variants in Water Channel Gene Tied to More Restful Sleep
Abby Olena | May 12, 2020
The gene, aquaporin-4, is critical in rodents for the cerebrospinal fluid bath the brain gets during sleep. It’s now also tied to slow wave electrical activity during deep sleep in people.
<em>The Scientist&nbsp;</em>Infographics: Editor&rsquo;s Picks of 2019
The Scientist Infographics: Editor’s Picks of 2019
Jef Akst | Dec 18, 2019
This year’s most beautiful illustrations covered topics including the molecular underpinnings of Parkinson’s disease and strategies for tracking marine organisms around the world’s oceans.