Tiny but powerful nanobodies may be the innovation that snuffs out the pandemic.

Understanding how the brain coordinates electrical activity could be key to developing more-effective treatments for a variety of brain disorders.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.

Authors of a new review urge researchers to consider how the chromosomal sex of a cell affects experiments in research on neurodegeneration.

Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.

Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Neanderthal DNA surprises in modern humans, the first blood test for Alzheimer’s, a discovery of new human salivary glands, and, oh yeah, a pandemic

Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.

An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.

Looking at the future of neurodegeneration research!

These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.

Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.

The Salk professor developed the institute’s first neurobiology lab and used it to develop cell lines, describe amyloid β toxicity, and screen for compounds that protect against neurodegeneration.

New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.

The authors propose that the shots might keep the immune system primed to battle diseases that would otherwise contribute to cognitive decline.