Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.
These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.
The Salk professor developed the institute’s first neurobiology lab and used it to develop cell lines, describe amyloid β toxicity, and screen for compounds that protect against neurodegeneration.