A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Alzheimer's Disease
The Biggest Science News of 2020
The Biggest Science News of 2020
Kerry Grens | Dec 23, 2020
Neanderthal DNA surprises in modern humans, the first blood test for Alzheimer’s, a discovery of new human salivary glands, and, oh yeah, a pandemic
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Lisa Winter | Dec 1, 2020
Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Ian Le Guillou | Nov 20, 2020
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
Ian Le Guillou | Oct 29, 2020
An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.
Breaking Down Barriers
Breaking Down Barriers
The Scientist Creative Services Team | Oct 19, 2020
Looking at the future of neurodegeneration research!
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Ian Le Guillou | Sep 28, 2020
These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.
Poor Sleep Linked with Future Amyloid-β Build Up
Poor Sleep Linked with Future Amyloid-β Build Up
Abby Olena | Sep 11, 2020
Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.
Neurobiologist Dave Schubert Dies
Neurobiologist Dave Schubert Dies
Kerry Grens | Aug 24, 2020
The Salk professor developed the institute’s first neurobiology lab and used it to develop cell lines, describe amyloid β toxicity, and screen for compounds that protect against neurodegeneration.