Different Dietary Fibers Affect the Body in Unique Ways

Acting through the microbiome, the fiber arabinoxylan reduces cholesterol in many people, while another fiber, called long-chain inulin, increases inflammation, a study finds.

Written byRachael Moeller Gorman
| 4 min read
A top-down view of bowls filled various high-fiber foods such as rice, corn, seeds, and cereal sitting on a wooden table.
Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

Fibers found in food are a motley bunch: some are long and straight, others branched and broad. They can have opposite charges and varied solubilities, and our foods contain them in assorted combinations and dosages. Despite this diversity, researchers often lump them together into one group—“dietary fiber”—which can muddy each fiber’s individual effects on the human body.

Researchers at Stanford University School of Medicine have started to untangle this figurative fiber jumble: they investigated the medical impact of two purified fibers in a randomized, longitudinal, crossover study in 18 volunteers published online April 27 in Cell Host & Microbe. The team found that various fibers have different, sometimes opposing effects on human health and uncovered some of the mechanisms that explain why.

Dietary fibers are carbohydrates from plants that humans cannot digest. Gut bacteria, however, can ferment them into short-chain fatty acids. The same bacteria also produce vitamins such as ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • After earning a bachelor’s degree in biology and neuroscience from Williams College, Rachael spent two years studying the tiny C. elegans worm as a lab tech at Massachusetts General Hospital/Harvard University. She then returned to school to get a master’s degree in environmental studies from Brown University, and subsequently worked as an intern at Scientific AmericanDiscover magazine, and the Annals of Improbable Research, the originators of the yearly Ig Nobel prizes. She now freelances for both scientific and lay publications, and loves telling the stories behind the science. Find her at rachaelgorman.com or on Instagram @rachaelmoellergorman.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies