Essential Genes Protected from Mutations

Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.

Written byDan Robitzski
| 6 min read
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Conventional wisdom suggests that evolution is driven by mutations that randomly occur throughout an organism’s genome, and that those that make the organism better at surviving or reproducing are then propagated thanks to natural selection. However, a new study cements the countering idea that the process of mutation isn’t evenly distributed across genomes. The work, published in Nature on January 12, finds that there’s a discrepancy in the rates of mutations among genes in the model plant Arabidopsis thaliana. Specifically, genes playing a crucial role in survival and reproduction mutate far less often than those that are less important.

Arabidopsis is a small flowering plant that has a comparatively small genome, making it a popular system for genetic research. The study, which began at the Max Planck Institute for Biology in Germany and was carried over to University of California, Davis, when lead author and plant scientist J. Grey Monroe ...

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    Dan is an award-winning journalist based in Los Angeles who joined The Scientist as a reporter and editor in 2021. Ironically, Dan’s undergraduate degree and brief career in neuroscience inspired him to write about research rather than conduct it, culminating in him earning a master’s degree in science journalism from New York University in 2017. In 2018, an Undark feature Dan and colleagues began at NYU on a questionable drug approval decision at the FDA won first place in the student category of the Association of Health Care Journalists' Awards for Excellence in Health Care Journalism. Now, Dan writes and edits stories on all aspects of the life sciences for the online news desk, and he oversees the “The Literature” and “Modus Operandi” sections of the monthly TS Digest and quarterly print magazine. Read more of his work at danrobitzski.com.

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