Essential Genes Protected from Mutations

Epigenetic structures appear to reduce the rate of changes in genes essential for survival and reproduction, a study finds, challenging the notion that mutations are evenly distributed throughout the genome prior to selection.

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Conventional wisdom suggests that evolution is driven by mutations that randomly occur throughout an organism’s genome, and that those that make the organism better at surviving or reproducing are then propagated thanks to natural selection. However, a new study cements the countering idea that the process of mutation isn’t evenly distributed across genomes. The work, published in Nature on January 12, finds that there’s a discrepancy in the rates of mutations among genes in the model plant Arabidopsis thaliana. Specifically, genes playing a crucial role in survival and reproduction mutate far less often than those that are less important.

Arabidopsis is a small flowering plant that has a comparatively small genome, making it a popular system for genetic research. The study, which began at the Max Planck Institute for Biology in Germany and was carried over to University of California, Davis, when lead author and plant scientist J. Grey Monroe ...

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    Dan Robitzski

    Dan is a News Editor at The Scientist. He writes and edits for the news desk and oversees the “The Literature” and “Modus Operandi” sections of the monthly TS Digest and quarterly print magazine. He has a background in neuroscience and earned his master's in science journalism at New York University.
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