Fecal Transplants More Successful from “Super-Donors”

A review finds that for several conditions, poop from certain healthy people is more likely to provide relief for recipients.

Written byShawna Williams
| 2 min read
an illustration of the human gut with bacteria inside

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: © ISTOCK.COM, GREENVECTOR

Not all poop is equally valuable, at least when it comes to fecal transplants. Some people, it appears, generate waste that is better at alleviating conditions associated with gut microbiome imbalances than others, according to a review article published yesterday (January 21) in Frontiers in Cellular and Infection Microbiology.

“Strategies to find super-donors whose stool is especially effective as a curative are still in their infancy, although progress on this topic—or making synthetic super-donors from the stool of many people—could greatly improve application of [faecal transplants],” Rob Knight, a microbiology researcher at the University of California, San Diego, who wasn’t involved in the review, tells The Guardian.

The authors of the paper looked at studies on the use of fecal microbiota transplants (FMT) to treat Clostridium difficile infection, inflammatory bowel disease, constipation, allergic colitis, and other conditions. They write in their conclusion that the existence of ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor’s degree in biochemistry from Colorado College and a graduate certificate in science communication from the University of California, Santa Cruz. Previously, she worked as a freelance editor and writer, and in the communications offices of several academic research institutions. As news director, Shawna assigned and edited news, opinion, and in-depth feature articles for the website on all aspects of the life sciences. She is based in central Washington State, and is a member of the Northwest Science Writers Association and the National Association of Science Writers.

    View Full Profile
Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Accelerating Recombinase Reprogramming with Machine Learning

Accelerating Recombinase Reprogramming with Machine Learning

Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

Thermo Fisher Logo

Products

waters-logo

Waters and BD's Biosciences & Diagnostic Solutions Business to Combine, Creating a Life Science and Diagnostics Leader Focused on Regulated, High-Volume Testing

zymo-research-logo

Zymo Research Partners with Harvard University to Bring the BioFestival to Cambridge, Empowering World-class Research

10x-genomics-logo

10x Genomics and A*STAR Genome Institute of Singapore Launch TISHUMAP Study to Advance AI-Driven Drug Target Discovery

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA