Fecal Transplants More Successful from “Super-Donors”

A review finds that for several conditions, poop from certain healthy people is more likely to provide relief for recipients.

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Not all poop is equally valuable, at least when it comes to fecal transplants. Some people, it appears, generate waste that is better at alleviating conditions associated with gut microbiome imbalances than others, according to a review article published yesterday (January 21) in Frontiers in Cellular and Infection Microbiology.

“Strategies to find super-donors whose stool is especially effective as a curative are still in their infancy, although progress on this topic—or making synthetic super-donors from the stool of many people—could greatly improve application of [faecal transplants],” Rob Knight, a microbiology researcher at the University of California, San Diego, who wasn’t involved in the review, tells The Guardian.

The authors of the paper looked at studies on the use of fecal microbiota transplants (FMT) to treat Clostridium difficile infection, inflammatory bowel disease, constipation, allergic colitis, and other conditions. They write in their conclusion that the existence of ...

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Meet the Author

  • Shawna Williams

    Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the University of California, Santa Cruz.
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