How Some Vaccines Protect Against More than Their Targets

As researchers test existing vaccines for nonspecific protection against COVID-19, immunologists are working to understand how some inoculations protect against pathogens they weren’t designed to fend off.

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As a physician-researcher specializing in infections in newborns, Tobi Kollmann is laser focused on how to stop babies from dying. While mortality for kids under five years old has dropped substantially in recent decades, he says, there has been little improvement in the rate of deaths in the first week of life. Indeed, of the 5.2 million children under 5 years old the World Health Organization estimates died last year of preventable or treatable causes, nearly half—2.4 million—died before reaching four weeks of age, and most newborn deaths occurred in the first week after birth. Having spent time in African countries where neonatal mortality is common and witnessed the frustration of colleagues there with their limited options for preventing it, Kollmann, now at the Telethon Kids Institute in Perth, Australia, says he wanted to find solutions that could be implemented immediately.

So when ...

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Meet the Author

  • Shawna Williams

    Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the University of California, Santa Cruz.

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