Infographic: Structure of the Perineuronal Net

See the web of proteins that make up these neuronal wrappings.

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

© 2018, LISA A. CLARK

© 2018, LISA A. CLARKThe PNN is composed of chondroitin sulfate proteoglycans (CSPGs), which are made of a core protein (blue) flanked by a number of sugar chains (dark purple). CSPGs bind to hyaluronic acid (pink balls), which is secreted by membrane-bound enzymes. Link proteins (orange) stabilize the interaction between hyaluronic acid and CSPGs. Sema3A and Otx2 (pink pyramid and red ball, respectively) bind to the sugar chains of the CSPGs. Tenascin-R (green) acts as a cross-linking protein among several CSPGs, contributing to the macromolecular assembly of the PNN.

Read the full story.

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Daniela Carulli

    This person does not yet have a bio.
Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo
New Frontiers in Vaccine Development

New Frontiers in Vaccine Development

Sino

Products

Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio
Inventia Life Science

Inventia Life Science Launches RASTRUM™ Allegro to Revolutionize High-Throughput 3D Cell Culture for Drug Discovery and Disease Research

An illustration of differently shaped viruses.

Detecting Novel Viruses Using a Comprehensive Enrichment Panel

Twist Bio