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Long-Lasting Wound Infections Linked to Microbes and Genetics

Two gene variations might help explain why some people experience chronic wounds.

Written byLisa Winter
| 2 min read

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ABOVE: Pathogenic bacteria such as Staphylococcus epidermidis, shown here, are more likely to emerge in wounds in which the diversity of other microbes is low.
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The paper

C. Tipton et al., “Patient genetics is linked to chronic wound microbiome composition and healing,” PLOS Pathog, 16:e1008511, 2020.

How quickly scrapes, cuts, and gashes in the skin heal can vary greatly depending on a person’s body mass, age, and whether the individual suffers from certain chronic conditions such as diabetes. Genetics, a new study suggests, may also play a role, with variations in two specific genes lowering the diversity of a wound’s microbiome and lengthening healing time.

Through a partnership with Southwest Regional Wound Care Center in Lubbock, Texas, geneticist Caleb Phillips at Texas Tech University and colleagues gained access to 85 patients’ DNA samples. Analyzing each person’s sample and comparing it to the diversity of bacteria in the ...

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Meet the Author

  • Lisa joined The Scientist in 2017. As social media editor, some of her duties include creating content, managing interactions, and developing strategies for the brand’s social media presence. She also contributes to the News & Opinion section of the website. Lisa holds a degree in Biological Sciences with a concentration in genetics, cell, and developmental biology from Arizona State University and has worked in science communication since 2012.

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