Mice Share Each Other’s Pain and Fear

The animals adopt the emotional state of their cagemates, and the parts of the brain engaged during the process are different for pain and fear, according to a new study.

amanda heidt
| 5 min read
neuroscience, mice, fear, pain, empathy, social transmission, emotion contagion, optogenetics, analgesia, Stanford University

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ABOVE: These mice were part of an experiment demonstrating that distinct neurological circuits control the empathetic responses of mice to a cagemate experiencing fear, pain, and pain relief.
MONIQUE SMITH AND BORIS HEIFETS

The ability to empathize with others stems from a long evolutionary history that includes empathy-like behaviors in animals beyond humans. Whales and primates grieve alongside members of their social groups, for example, while rodents are able to recognize and respond to the fear and pain of their neighbors.

A study published January 8 in Science has found that the brain circuits engaged during empathetic behaviors in mice differ depending on the emotion they are experiencing. The social transmission of pain, for example, is mediated by a pathway involving the brain’s anterior cingulate cortex (ACC) and the nucleus accumbens (NAc), while empathy-based fear is dictated by projections leading from the ACC to a region called the basolateral amygdala (BLA). ...

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Meet the Author

  • amanda heidt

    Amanda Heidt

    Amanda was an associate editor at The Scientist, where she oversaw the Scientist to Watch, Foundations, and Short Lit columns. When not editing, she produced original reporting for the magazine and website. Amanda has a master's in marine science from Moss Landing Marine Laboratories and a master's in science communication from UC Santa Cruz.
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