New Understanding of Metastasis Could Lead to Better Treatments

Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.

Written byShawna Williams
| 17 min read

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Eight years ago, Adrienne Boire had a conversation with a patient that would set the course of her research. Back then, she was dividing her time between her postdoctoral research in a lab studying metastasis at Memorial Sloan Kettering Cancer Center and treating patients there as part of a clinical fellowship. The patient, like Boire, was in her 30s, and she had recently been diagnosed with a condition called leptomeningeal metastasis, in which cancer cells invade the spinal fluid, causing death within a few months. “She asked me deceptively simple questions,” Boire remembers, “like, ‘Why did this happen to me? Why did my cancer go into the spinal fluid? How did it get there?’ . . . And, obviously, ‘What can we do to stop this?’” Boire didn’t have good answers. “And then she said, ‘I really hope somebody will study this someday.’”

Boire agreed with ...

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Meet the Author

  • Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor’s degree in biochemistry from Colorado College and a graduate certificate in science communication from the University of California, Santa Cruz. Previously, she worked as a freelance editor and writer, and in the communications offices of several academic research institutions. As news director, Shawna assigned and edited news, opinion, and in-depth feature articles for the website on all aspects of the life sciences. She is based in central Washington State, and is a member of the Northwest Science Writers Association and the National Association of Science Writers.

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Published In

April 2021

Advancing Against Metastasis

Cancer cells can spread early and lie dormant for years

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