Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
ABOVE: © ISTOCK.COM, LIBRE DE DROIT
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

ABOVE: © ISTOCK.COM, LIBRE DE DROIT

metastasis

illustration of a blood vessel
Bacteria in Tumors Promote Metastasis in Mice
Sophie Fessl | Apr 7, 2022
Microbes living inside cancer cells may help them spread to distant sites by enhancing the cells’ resistance to mechanical stress, a study shows.
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez | Mar 25, 2022
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
Mammary tumor organoids undergo a radical shape shift when treated with a microRNA.
Organoid Shape Identifies Potential Cancer Drugs
Roni Dengler, PhD | Aug 3, 2021
An unusual drug screen takes advantage of “porcupine-like” structures of cancer cells in 3D organoids.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
illustration of blue cancer cell extending tendrils around itself
Janus-Faced Neutrophils
Sophie Fessl | Mar 2, 2022
The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.
Homing Technology Delivers Therapy to Cancerous Bone
Roni Dengler, PhD | Jul 19, 2021
A clever approach to modifying already existing cancer therapies may be a game changer for treating metastatic breast cancer.
Conceptual image showing fragmented X chromosomes
How Chaos in Chromosomes Helps Drive Cancer Spread
Samuel F. Bakhoum | Mar 1, 2022
A new link between inflammation and rampant chromosomal abnormalities reveals novel strategies to treat diverse malignancies.
Infographic showing how bursting micronuclei promote cancer
Infographic: Chromosome Errors Cause Micronuclei and Drive Cancer
Samuel F. Bakhoum | Mar 1, 2022
When micronuclei rupture, chromosomes break, recombine, and form circles, causing inflammation and promoting carcinogenic growth.
Best of Cancer Research
The Scientist Creative Services Team | Sep 23, 2020
This collection of articles from The Scientist explores some of the latest cancer research!
Scientific illustration of a migrating breast cancer cell.
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis
Alejandra Manjarrez | Feb 4, 2022
A study uncovers a novel connection between the biomolecule and cancer progression.
A compilation of several images, including a dog, a blind mole rat, and cell micrographs
Our Favorite Cancer Stories of 2021
Amanda Heidt | Dec 9, 2021
This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.
The Scientist Speaks Podcast – Episode 6
The Scientist Creative Services Team | Jun 30, 2020
A Game of Cancer and Evolution
brain scan showing uptake of tratuzumab into tumor (arrow)
Sound Waves Aid Brain Tumor Treatment
Ruth Williams | Oct 13, 2021
In a small clinical study, focusing ultrasound beams on tumors in patients’ brains helped open the blood-brain barrier to facilitate drug delivery.
a leopard gecko with an unusually yellow body
“Lemon Frost” Leopard Geckos’ Cancers Similar to Human Melanomas
Christie Wilcox | Jun 24, 2021
The color morph’s bright yellow hue and its propensity for skin tumors both likely stem from a gene implicated in a dangerous form of human skin cancer, suggesting the animals could make an ideal model for studying the disease.
photograph of john pawalek in a navy blue suit and red tie
John Pawelek, Who Explored the Causes of Metastasis, Dies at 79
Marcus A. Banks | Jun 22, 2021
The Yale School of Medicine cancer researcher doggedly pursued the question of how cancer spreads.
illustrations of cancer cells dividing in pink tones
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Marcus A. Banks | Jun 17, 2021
Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.
screen shot from a microscopy video of a green cell exiting a red cell and then entering two other green cells in sequence as a yellow arrow follows the original green cell
Cancer Cells Parasitize Other Ones to Survive: Study
Marcus A. Banks | May 13, 2021
Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.
Infographic: Steps in Cancer Metastasis
Shawna Williams | Apr 1, 2021
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lie dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
A Bright New Tool to Record Cellular Interactions
Lisa Winter | Apr 1, 2021
The G-baToN prototype transfers GFP between cells, illuminating cell-cell contacts.