More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

Microbes living inside cancer cells may help them spread to distant sites by enhancing the cells’ resistance to mechanical stress, a study shows.

A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.

Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.

The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.

A new link between inflammation and rampant chromosomal abnormalities reveals novel strategies to treat diverse malignancies.

When micronuclei rupture, chromosomes break, recombine, and form circles, causing inflammation and promoting carcinogenic growth.

A study uncovers a novel connection between the biomolecule and cancer progression.

This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.

In a small clinical study, focusing ultrasound beams on tumors in patients’ brains helped open the blood-brain barrier to facilitate drug delivery.

The color morph’s bright yellow hue and its propensity for skin tumors both likely stem from a gene implicated in a dangerous form of human skin cancer, suggesting the animals could make an ideal model for studying the disease.

The Yale School of Medicine cancer researcher doggedly pursued the question of how cancer spreads.

Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.