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A colorful image of a tumor
Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy
Research into how pancreatic tumors adapt to stress could lead to a new treatment approach.
Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy
Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy

Research into how pancreatic tumors adapt to stress could lead to a new treatment approach.

Research into how pancreatic tumors adapt to stress could lead to a new treatment approach.

tumor microenvironment
Micrograph image of cancer cells stained violet.
Oral Cancer Survives Starvation with Help from Nearby Nerves
Dan Robitzski | Nov 16, 2022 | 3 min read
Human and mouse oral tumors recruit nerves to produce peptides that the cancer cells need to survive—but this process can be blocked with a migraine drug.
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
Single Cell and Spatial Imaging of the Tumor Microenvironment
A Guide to Mapping the Complexity of the Tumor Microenvironment
The Scientist Creative Services Team | 1 min read
High-quality sample preparation, single-cell analysis, and ultra-high content spatial proteomics for multi-dimensional research workflows.
two glowing neuronlike macrophages
Immune Cells Imitating Neurons Cause Pain in Mice with Tumors
Shafaq Zia | Oct 18, 2022 | 3 min read
Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.
outline of a brain slice with white patch surrounded by teal
Astrocytes Feed Glioblastoma, Promoting Tumor Growth: Mouse Study
Patience Asanga | Oct 5, 2022 | 3 min read
Starving glioblastoma tumors of the cholesterol made by astrocytes could suppress brain cancer progression.
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Building Cancer Models with Creative Collaborators
Deanna MacNeil, PhD | 1 min read
Jennifer Munson shares how teamwork and collaboration have fostered her research at the intersection of creativity and clinical discovery.
Photograph of Humsa Venkatesh
Humsa Venkatesh Probes Cancer’s Grip on the Brain
Maddie Bender | Aug 15, 2022 | 3 min read
At Brigham and Women’s Hospital, the cancer biologist is combining research into the tumor microenvironment with the principles of neuroscience to tease apart how cancers grow—and how to stop them.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022 | 3 min read
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Learn about innovations in tissue regeneration 
Stem Cell Engineering for Tissue Regeneration
The Scientist Creative Services Team | 1 min read
Innovative strategies drive stem cell repair of organ damage.
Tumor microbiome composite
Could Cancer’s Microbiome Help Diagnose and Treat the Disease?
Jef Akst | Mar 14, 2022 | 10+ min read
A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.
Illustration showing microbial signatures of cancer in the body
Infographic: Putting Cancer’s Unique Microbiomes to Use
Jef Akst | Mar 14, 2022 | 1 min read
From diagnosis to tracking treatment responses, bacteria and other microbes in the blood, gut, and tumors of cancer patients may provide helpful hints for improving their care.
jigsaw puzzle with magnifying glass over the word "metastasis" 
Breast Cancer Cells Retrain T Cells to Invade Specific Tissues
Nele Haelterman, PhD | 3 min read
Scientists discover tumor-associated T cells that drive breast cancer metastasis to lymph nodes.
illustration of blue cancer cell extending tendrils around itself
Janus-Faced Neutrophils
Sophie Fessl, PhD | Mar 2, 2022 | 4 min read
The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021 | 10+ min read
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
Overcoming T Cell Therapy Barriers with Engineered Proteins
Overcoming T Cell Therapy Barriers with Engineered Proteins
The Scientist Creative Services Team | 1 min read
Shannon Oda will discuss how to develop novel engineered fusion proteins to improve T cell therapies against hematological and solid tumors.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021 | 6 min read
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
Exploring the Matrix: A Profile of Zena Werb
Diana Kwon | Dec 1, 2019 | 7 min read
The cell and molecular biologist unveiled a role for the breakdown of proteins in the extracellular matrix in both healthy and pathogenic cells.
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Fortis Life Sciences | 3 min read
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Jim Daley | Apr 1, 2018 | 2 min read
Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.
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