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Four circular maps of color-coded immune cell types corresponding to the four tumor microenvironment archetypes.
A Bird’s Eye View of the Tumor Microenvironment
Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.
A Bird’s Eye View of the Tumor Microenvironment
A Bird’s Eye View of the Tumor Microenvironment

Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.

Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.

tumor microenvironment

A microscopy image stained for different cell populations in breast tumors.
Cancer Cells Give Orders
Holly Barker, PhD | Apr 23, 2024 | 4 min read
Cancer-supporting cells control their neighbors’ behavior using an often-overlooked protein delivery system. 
Toppling the Genetic Dominoes in Bone Metastasis
Laura Tran, PhD | Feb 15, 2024 | 4 min read
A key gene that fuels the molecular cascade driving prostate cancer bone metastasis progression may open avenues for targeted therapies.
An illustration of cells growing in the presence of cytokines.
Advancing Immunotherapy Development with High-Quality Cytokines
The Scientist and Sino Biological | 3 min read
Superior quality cytokines are crucial for reliable research results and the safe production of cancer cell therapies.
Image of spatial transcriptomic spots superimposed onto a stained tissue section.
Poor Cancer Prognosis Associated with a Transcriptional Signature
Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read
Researchers connect a tumor’s leading edge transcriptional profile to poor survival outcomes across cancer types. 
Medical illustration of brain cancer with a microscopic magnification of malignant cells dividing in the tumor microenvironment.
Capturing the Brain Tumor Microenvironment with Tissue Engineering
Deanna MacNeil, PhD | Aug 4, 2023 | 3 min read
Researchers built a 3D glioblastoma model to study therapeutic resistance and improve drug screening systems.
Viewing the Glioblastoma Tumor Microenvironment at Single Cell Resolution
Viewing the Glioblastoma Tumor Microenvironment at Single Cell Resolution
The Scientist Staff | 1 min read
In this webinar, Matthias Brendel will discuss a new PET approach called scRadiotracing, which involves immunomagnetic cell sorting after in vivo radiotracer injection combined with 3D histology.
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
The Biofilm Life Cycle
Infographic: Stages of Biofilm Formation
Holly Barker, PhD | Jun 1, 2023 | 1 min read
Free-swimming bacteria settle on a surface to cooperate and form a protective biofilm.
<em >Immunohistochemistry: Origins, Tips, and a Look to the Future</em>
Immunohistochemistry: Origins, Tips, and a Look to the Future
Steven Hrycaj, PhD | 7 min read
An essential staining technique with a long history, immunohistochemistry (IHC) is being upgraded for modern research and clinical applications.
Green and brown illustration of cancer cells in front of a peach and yellow background.
Bacterial Tractor Beams Bring Radiation to Tumors
Rachael Moeller Gorman | Apr 17, 2023 | 3 min read
Colonizing tumors with engineered bacteria may allow researchers to target sites currently inaccessible to radionuclide therapy.
Portrait of Alex Muir
Alex Muir Explores Cancer Cells’ Menu
Natalia Mesa, PhD | Mar 1, 2023 | 3 min read
The University of Chicago cell biologist is studying how the nutrients available to cancers influence their growth. 
Cancer Vaccines: A Dose of Prevention
Cancer Vaccines: A Dose of Prevention
The Scientist | 1 min read
Discover the latest progress behind therapeutic vaccines that boost the immune system’s cancer-killing abilities.
A colorful image of a tumor
Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy
Chengsheng Wu, David Cheresh, and Sara Weis; The Conversation | Jan 17, 2023 | 5 min read
Research into how pancreatic tumors adapt to stress could lead to a new treatment approach.
Micrograph image of cancer cells stained violet.
Oral Cancer Survives Starvation with Help from Nearby Nerves
Dan Robitzski | Nov 16, 2022 | 3 min read
Human and mouse oral tumors recruit nerves to produce peptides that the cancer cells need to survive—but this process can be blocked with a migraine drug.
<em >The Scientist</em>&rsquo;s Journal Club: Cancer
The Scientist’s Journal Club: Cancer
The Scientist | 1 min read
Scientists present the latest research on immune cell responses to cancer, the role of epigenetics in cancer, and molecular imaging of the tumor microenvironment.
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
two glowing neuronlike macrophages
Immune Cells Imitating Neurons Cause Pain in Mice with Tumors
Shafaq Zia | Oct 18, 2022 | 3 min read
Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.
Abstract rendering of a tumor and its microenvironment in purple
The Basics of the Tumor Microenvironment
Johanna Pruller, PhD | 4 min read
Learn about the tumor microenvironment (TME), a key influencer of cancer growth, spread, and treatment success.
outline of a brain slice with white patch surrounded by teal
Astrocytes Feed Glioblastoma, Promoting Tumor Growth: Mouse Study
Patience Asanga | Oct 5, 2022 | 3 min read
Starving glioblastoma tumors of the cholesterol made by astrocytes could suppress brain cancer progression.
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