A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
ABOVE: © iStock.com, OGPHOTO
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer

Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.

Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.

ABOVE: © iStock.com, OGPHOTO

tumor microenvironment

Tumor microbiome composite
Could Cancer’s Microbiome Help Diagnose and Treat the Disease?
Jef Akst | Mar 14, 2022
A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.
Illustration showing microbial signatures of cancer in the body
Infographic: Putting Cancer’s Unique Microbiomes to Use
Jef Akst | Mar 14, 2022
From diagnosis to tracking treatment responses, bacteria and other microbes in the blood, gut, and tumors of cancer patients may provide helpful hints for improving their care.
Examine Altered Glycobiology in Cancer
Examining Altered Glycobiology in Cancer
The Scientist Creative Services Team, Vector Laboratories | Mar 23, 2022
Changes to protein glycosylation play a major role in dictating cancer progression and prognosis, but could they also present biomarkers or therapeutic targets?
illustration of blue cancer cell extending tendrils around itself
Janus-Faced Neutrophils
Sophie Fessl | Mar 2, 2022
The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
How Cancer Circumvents the Immune System
How Cancer Circumvents the Immune System
The Scientist Creative Services Team in collaboration with Bio-Techne | Dec 15, 2021
Dario Vignali and Peter Westcott will explore the importance of understanding immune-cancer mechanistic interactions for developing therapeutic approaches.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
Exploring the Matrix: A Profile of Zena Werb
Diana Kwon | Dec 1, 2019
The cell and molecular biologist unveiled a role for the breakdown of proteins in the extracellular matrix in both healthy and pathogenic cells.
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A 3-D Tumor Microenvironment for Personalized Immunotherapy
Roni Dengler, PhD | Sep 10, 2021
A new platform enables screening a wide range of combination anticancer therapeutics in a matter of days, which may translate to personalized therapeutic regimens for patients in less time.
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Jim Daley | Apr 1, 2018
Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
Image of the Day: Sun Burn
The Scientist Staff, The Scientist Staff | Oct 20, 2017
When certain melanocyte stem cells are exposed to UV rays, a molecular cascade can trigger melanoma, scientists find in mice.
Cancer and Its Milieu
The Scientist Staff | Mar 31, 2017
Lawrence Berkeley National Laboratory researcher and April profilee Mina Bissell explains the intricacies of how cancer takes hold in a body.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | Sep 10, 2021
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
Cancer's Vanguard
Catherine Offord | Apr 1, 2016
Exosomes are emerging as key players in metastasis.
The Scientist on the Pulse, April 23
Kerry Grens | Apr 23, 2015
Hot topics in cancer research from the annual meeting of the American Association for Cancer Research
Improving Cancer Immunotherapy with Anti-Cancer Adenoviruses
The Scientist Creative Services Team, IsoPlexis | Jun 25, 2021
Researchers use a mesenchymal stromal cell-based vector to deliver multiple viruses simultaneously to improve CAR-T cell anti-tumor activity.
Contributors
Jenny Rood | Apr 1, 2015
Meet some of the people featured in the April 2015 issue of The Scientist.