Opinion: Three-Parent Embryos—A Slippery Slope?

The use of pronuclear transfer to treat infertility must first be backed by evidence it can work in cases where parents seek to avoid mitochondrial mutations.

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ISTOCK, VCHALJohn D. Loike, a Professor of Biology at Touro College and University Systems, writes a regular column on bioethics for The Scientist.

On June 7, news reports emerged that Valery Zukin, director of Nadiya Clinic of Reproductive Medicine in Ukraine, and his colleagues had created four children from “infertile” older women using DNA obtained from three different parents. The technique, called pronuclear transfer, has entered clinical trials in the U.K. to help fertile women with devastating mitochondrial DNA (mtDNA) mutations to have healthy babies, but not to treat infertility. It’s our position that it is premature to apply pronuclear transfer to treat infertile women for both scientific and ethical reasons until more clinical research has been performed on women with mtDNA mutations.

In pronuclear transfer, a man’s sperm is used to generate two fertilized eggs: one obtained from his female partner who has the mtDNA mutations and ...

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Meet the Author

  • John Loike

    John D. Loike

    John Loike serves as the interim director of bioethics at New York Medical College and as a professor of biology at Touro University. His biomedical research focuses on how human white blood cells combat infections and cancer.
  • Alan Kadish

    Alan Kadish

    Alan Kadish is president of the Touro University System, the largest Jewish-sponsored educational institution in the United States. Before becoming Touro’s second president in March 2010, Kadish distinguished himself as a cardiologist, teacher, researcher, and administrator.
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