Protein Spurs T-Cell Proliferation

A newly discovered protein promotes immunity to viruses and cancer by triggering the production of cytotoxic T cells.

Written byJef Akst
| 2 min read

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Human T cellFLICKR, NIAIDEditor’s note (December 16, 2016): This paper has been retracted.

After a genetic mouse screen revealed a strain of mice that produced 10 times as many cytotoxic T cells as its wild-type counterparts when infected with a virus, researchers knew they were onto something interesting. The mice not only suppressed viral infections more effectively, but those infections spurred the production of more memory T cells that allowed the animals to mount an even more efficient response to the virus upon reinfection. Finally, the mice were also more resistant to cancer.

“The discovery of a protein that could boost the immune response to not only cancer, but also to viruses, is a fascinating one,” Mike Turner, head of infection and immunobiology at the Wellcome Trust who was not involved in the study, said in a press ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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