Reshuffled Genomes May Explain Cephalopods’ Smarts

In two related studies, researchers describe huge chromosomal rearrangements and about 500 novel gene clusters in the octopus, squid, and cuttlefish genomes, which they say could help explain how they evolved their extraordinary brains.

Written bySophie Fessl, PhD
| 4 min read
A Hawaiian bobtail squid (Euprymna scolopes) rests on a reflective surface
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Octopuses, squids, and cuttlefish—together referred to as the coleoid, or soft-bodied, cephalopods—are astonishingly clever, dextrous, and ingenious. They problem solve, plan for the future, and have the largest nervous systems among invertebrates. Now, two recent studies with some shared coauthors that were published in Nature Communications on April 21 and May 4, uncover chromosomal restructuring that may explain how the novelties of this curious group evolved.

Gül Dölen, a neuroscientist at Johns Hopkins University who was not involved in either study, says the studies will help scientists understand how genes, synapses, and circuits produce complex behaviors. “As a neurobiologist interested in understanding brain evolution, I think this is a major step forward.”

In 2015, some of the authors behind the new studies sequenced the first cephalopod genome, that of the California two-spot octopus (Octopus bimaculoides). At that time, the researchers noticed that the animal’s genes appeared to be arranged differently ...

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  • Headshot of Sophie Fessl

    Sophie Fessl is a freelance science journalist. She has a PhD in developmental neurobiology from King’s College London and a degree in biology from the University of Oxford. After completing her PhD, she swapped her favorite neuroscience model, the fruit fly, for pen and paper.

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