Sniffing out Alzheimer’s

A peanut-butter smell test could help diagnose the neurodegenerative disease in its early stages.

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

FLICKR, DENISE KREBSIn a small pilot study of patients displaying signs of cognitive decline, researchers at the McKnight Brain Institute Center for Smell and Taste and the University of Florida (UF) found that peanut butter can help identify those with Alzheimer’s disease (AD), a neurodegenerative disorder often accompanied by a loss of smell.

Working with 18 patients with probable AD, 24 with mild cognitive impairment, 26 with other causes of dementia, and 26 matched controls, graduate student Jennifer Stamps and her UF advisor Kenneth Heilman measured the distance from the nose at which a patient (whose eyes were closed) could smell a tablespoon of peanut butter. They ran the test one nostril at a time and found that early-stage AD patients had dramatically different smell sensitivity between the right and left nostrils, with the left regularly being more severely impaired. The other patients tested displayed no such difference in smell sensitivity.

“Portions of olfactory cortex are the initial sites of AD pathology, and patients with AD often have more degeneration of their left than right hemisphere,” the authors ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
Share
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Faster Fluid Measurements for Formulation Development

Meet Honeybun and Breeze Through Viscometry in Formulation Development

Unchained Labs
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital

Products

Atelerix

Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome