FLICKR, RUTH HARTNUPThe first ever trial to treat humans with a treatment derived from induced pluripotent stem cells (iPSCs) is set to begin. Soon—“within days,” Nature reported one RIKEN source as saying—researchers at the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, will transplant sheets of retinal pigment epithelial cells derived from an age-related macular degeneration (AMD) patient’s own skin cells to replace damaged cells of the retina.
CDB ophthalmologist Masayo Takahashi and her collaborators have tested the autologous treatment in monkeys, showing that the animals mounted no immune response that resulted in the cells’ rejection. Studies in mice and monkeys have also demonstrated that the therapy is unlikely to cause tumors, a concern with injecting iPSCs and embryonic stem cells into the body. To further ensure the safety of patients in this first trial, the researchers have performed genetic stability tests on the cells they plan to implant.
The first transplant surgery will be performed at the Institute of Biomedical Research and Innovation in Kobe. Trial researchers will eventually transplant autologous cells into six AMD patients, who will be monitored for one year following the procedure.
“While I worry that researchers in ...
