Graphic showing Cas9 introducing blunt end double-strand breaks in DNA while Cas12a introduces staggered cuts in the DNA.

| 2 min read

What’s the Difference Between Cas9 and Cas12a Nucleases?

Both Cas9 and Cas12a cleave DNA, but they differ in how they cut the molecule.

| 2 min read

Lonza and Vertex Sign a Long-Term Commercial Supply Agreement for CASGEVY® (exagamglogene autotemcel)

Two hands holding tweezers and dissecting single points in a DNA sequence.

| 5 min read

From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution

Cas9

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

Available on Demand

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

Available on Demand

Blue DNA double helix breaking apart.

Keeping Telomeres in Their Places

Aparna Nathan, PhD | | 4 min read

3D structural model of a Cas protein and sgRNA targeting and unwinding DNA for gene editing.

CRISPR Gene Editing: Cas9 and Beyond

Deanna MacNeil, PhDandJohanna Pruller, PhD | | 7 min read

Glowing red DNA on bluish background

Redesigning Medicine Using Synthetic Biology

Alison Halliday, PhDandTechnology Networks | | 5 min read

Cas9 enzyme

Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control

Ida Emilie Steinmark, PhD | | 3 min read

Explore How Microplate-Based Cellular Assays Advance Life Science Research

Elevate Cellular Assays with Microplate Readers

BMG LABTECH | | 1 min read

3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.

A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage

Deanna MacNeil, PhD | | 3 min read

Fluorescent microscopy images of cells after being transfected.

Universal Transfection Reagents: Improving Efficiency and Decreasing Cell Toxicity

Roche,MilliporeSigmaandThe Scientist | | 4 min read

iStock

Optimizing Clinical Cell Therapy Manufacturing

Thermo Scientific | | 1 min read

Two prime editing guide RNAs (pegRNAs), deliver Cas9 enzymes to targeted regions of the genome.

Infographic: Two Guide RNAs Make for Large, Stable Insertions

Dan Robitzski | | 1 min read

Genetic Syndrome and Genetic Disorder, 3D illustration of science concept.

With Two RNA Guides, Editing Technique Writes Long DNA Insertions

Dan Robitzski | | 4 min read

A cockroach clings to the inside of a white mug.

Injecting Cockroaches with CRISPR Gene Edits Their Offspring

Sophie Fessl, PhD | | 4 min read

ERS iStock photo

Picking the Right CRISPR System

ERS Genomics | | 1 min read

cartoon depiction of a pair of scissors about to cut a DNA double helix

Researchers Uncover New Families of Gene-Editing Enzymes

Annie Melchor | | 2 min read

800x560-stock-only

Introduction to CRISPR Genome Editing

Synthego | | 1 min read

cartoon showing a hand taking a tool to a double-helix of DNA to represent gene editing

WHO Releases New Recommendations on Human Genome Editing

Annie Melchor | | 3 min read

feluda cas9 fncas9 covid-19 sars-cov-2 diagnostics coronavirus pandemic india

Assay for Sickle Cell Anemia Is Repurposed to Diagnose COVID-19

G.B.S.N.P. Varma | | 5 min read

CRISPR, Cas-9, Nobel, Chemistry

CRISPR’s Adaptation to Genome Editing Earns Chemistry Nobel

Amanda Heidt | | 4 min read

Symptoms in ALS Mouse Model Improve with CRISPR Base Editing

Abby Olena, PhD | | 4 min read

Page 1 of 3 - 48 Total Items

Trending

An illustration of red-colored meat products against a peach background.

The Alpha-Gal Syndrome Story: How Researchers Traced a Red-Meat Allergy to Ticks

At the intersection of a red meat allergy and a cancer-drug reaction investigations, researchers pinned a lone star culprit.

Many spiral-shaped orange Borrelia bacteria.

Fragments of Lyme Disease Bacteria Linked to Liver Dysfunction

Cell wall components from Borrelia burgdorferi lingered in the mouse liver for weeks, suggesting new therapeutic avenues for this chronic disease.

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

Drying cloths dyed with a red pigment.

A Fungus, Not Its Insect Host, Paints the World Red

Lac insects carry a yeast-like symbiont that produces a commercially important bright red pigment, revealing insights about insect-microbe symbiosis.

Multimedia

Conceptual image of automated liquid handling showing multiple pipette tips dispensing blue fluid into a multi-well dish.

Advances in Automated RNA Library Preparation

Whole transcriptome sequencing RNA library preparation gets a boost from the latest automated liquid handling technology.

Accelerating Recombinase Reprogramming with Machine Learning

Accelerating Recombinase Reprogramming with Machine Learning

In this webinar, Felix Lansing will discuss how AI-driven models improve recombinase development.

July Digest 2025

July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue

Research Resources

Podcasts

Webinars

Videos

Infographics

eBooks

Accelerating Recombinase Reprogramming with Machine Learning

Accelerating Recombinase Reprogramming with Machine Learning

In this webinar, Felix Lansing will discuss how AI-driven models improve recombinase development.

Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

In this webinar, Brian Hie will discuss Evo2, a state-of-the-art genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins.

Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

In this webinar, learn how scientists use advanced human brain models to uncover treatment strategies for complex neurological conditions.

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

In the dynamic biotechnology and biopharmaceutical science fields, qPCR and dPCR multiplexing has emerged as a crucial technique for accelerated and consistent research workflows.

Products

Product News

Waters and BD's Biosciences & Diagnostic Solutions Business to Combine, Creating a Life Science and Diagnostics Leader Focused on Regulated, High-Volume Testing

Strong strategic fit that increases presence in multiple high-growth adjacencies and offers immediate commercial impact from Waters' proven execution model

Zymo Research Partners with Harvard University to Bring the BioFestival to Cambridge, Empowering World-class Research

Zymo Research, a global leader in sample preparation technologies and sustainable life science solutions, will partner with Harvard University to host the BioFestival on October 18, 2025.

10x Genomics and A*STAR Genome Institute of Singapore Launch TISHUMAP Study to Advance AI-Driven Drug Target Discovery

Ambitious study will profile thousands of tumor samples to uncover novel biomarkers and therapeutic targets for cancer and inflammatory diseases

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Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

This new product line is specifically engineered to meet the rigorous demands of immunology research, vaccine development, animal studies, cell and gene therapy, and therapeutic protein manufacturing.