Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing

Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.

Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.

Cas9
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
Emma Yasinski | Oct 21, 2019
In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.
First Successful Gene Drive in Mammals
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
Abby Olena | Sep 12, 2018
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Methods to Detect CRISPR Off-Target Mutations
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Feb 28, 2018
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
Most Accurate CRISPR Gene Editing Yet
Most Accurate CRISPR Gene Editing Yet
Kerry Grens | Sep 22, 2017
A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.
CRISPR Corrects RNA-based Disease Defects
CRISPR Corrects RNA-based Disease Defects
Kerry Grens | Aug 10, 2017
In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.
Details Published on CRISPR-treated Embryos
Details Published on CRISPR-treated Embryos
Kerry Grens | Aug 2, 2017
Scientists correct a mutation in fertilized eggs that causes a severe cardiac disease.
Scientists Destroy Entire Chromosome with CRISPR
Scientists Destroy Entire Chromosome with CRISPR
Kerry Grens | Aug 1, 2017
Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.
Human Genetic Variation May Complicate CRISPR
Human Genetic Variation May Complicate CRISPR
Ashley Yeager | Jul 31, 2017
Slight sequence differences confound target sites in precision genome-editing, a study shows.