A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

Researchers have developed a variety of techniques to detect when CRISPR misses the mark.

A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.

In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.

Scientists correct a mutation in fertilized eggs that causes a severe cardiac disease.

Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.

Slight sequence differences confound target sites in precision genome-editing, a study shows.

AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.

A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.