New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

Cas9
New Methods to Detect CRISPR Off-Target Mutations
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
Most Accurate CRISPR Gene Editing Yet
Most Accurate CRISPR Gene Editing Yet
Kerry Grens | Sep 22, 2017
A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.
CRISPR Corrects RNA-based Disease Defects
CRISPR Corrects RNA-based Disease Defects
Kerry Grens | Aug 10, 2017
In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.
Details Published on CRISPR-treated Embryos
Details Published on CRISPR-treated Embryos
Kerry Grens | Aug 2, 2017
Scientists correct a mutation in fertilized eggs that causes a severe cardiac disease.
Scientists Destroy Entire Chromosome with CRISPR
Scientists Destroy Entire Chromosome with CRISPR
Kerry Grens | Aug 1, 2017
Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.
Human Genetic Variation May Complicate CRISPR
Human Genetic Variation May Complicate CRISPR
Ashley Yeager | Jul 31, 2017
Slight sequence differences confound target sites in precision genome-editing, a study shows.
Anti-CRISPR Protein Reduces Off-Target Effects
Anti-CRISPR Protein Reduces Off-Target Effects
Diana Kwon | Jul 12, 2017
AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.
Was a Drop in CRISPR Firms’ Stock Warranted?
Was a Drop in CRISPR Firms’ Stock Warranted?
Claire Asher | Jun 7, 2017
A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.
Smallest Cas9 Ortholog Reported
Smallest Cas9 Ortholog Reported
Tracy Vence | Feb 23, 2017
Researchers demonstrate the delivery of AAV-packaged CRISPR-CjCas9 into the muscles and eyes of mice.