An illustration that shows researchers and medicines.

| 3 min read

A New Initiative Bridges the Gap Between Discovery and Drug Development

The initiative combines coursework, networking, and a task force to provide scientists with real-world knowledge on drug development to translate basic research into therapies.

A photo of a scientist pipetting samples into a 96-well microplate.

| 1 min read

Addressing Antibody Developability Challenges Earlier

Glass balls form chemical rings, representing the complicated and ring structures of macrocyclic peptides.

| 5 min read

Engineered Enzymes Streamline Synthesis of an Oral Cholesterol Drug

drug manufacturing

An empty lipid nanoparticle called a pre-formed vesicle is shown in blue against a black background.

Cargo-free LNP Manufacturing Could Spark a Nucleic Acid Therapy Renaissance

By Ying K. Tam, PhD and Paulo Lin, PhD | | 6 min read

A hand in a blue glove holds a white chicken egg while a syringe is inserted into the yolk.

Chicken Eggs Become Bioreactors to Brew Low-Cost Medicines

By Meenakshi Prabhune, PhD | | 4 min read

Genetic manipulation and DNA modification concept

Strategies for Building Scalable Gene Editing Programs

By Danaher | | 1 min read

Abstract illustration of a red cancer cell interacting with a blue immune cell

Turning Cell Therapy Into a Scalable Medicine

By The Scientist and Cellares | | 6 min read

A magnifying glass over a regulatory compliance checklist icon

Addressing Noncompliance in Drug Development

By ELGA VEOLIA | | 1 min read

A rendering of abstract 3-D molecular structures on a white-grey background.

Advancing Analytical Solutions with Cutting-Edge Approaches

By Danaher | | 1 min read

Three clear pill capsules are shown with a silver DNA molecule shown in each one, representing personalized genomic medicine for a rare disease.

FDA Proposes Speedy “Plausible Mechanism Framework” for Rare Disease Drug Development

By Stephanie DeMarco, PhD | | 4 min read

Chimeric antigen receptors expressed by a T cell binding to the membrane surface receptor on a cancer cell

Making In Vivo Progress in CAR Therapeutic Development

By The Scientist and ACROBiosystems | | 2 min read

An illustration of pink rod-shaped bacteria suspended in front of a dark background.

From LAL to Recombinant Cascade Reagents: Implementing Animal-Free Endotoxin Testing

By Charles River Laboratories, Inc. and The Scientist | | 3 min read

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Image of Nobel Prize medal on a table.

Who Will Win the 2026 Nobel Prize? Scientists Make Their Predictions

From GLP-1 pioneers to researchers who uncovered the genetic roots of narcolepsy, scientists reveal who they think could receive a call from the Nobel Committee this year.

A photograph of a rattlesnake against a jungle-like background.

Vipers’ Self-Defense Mechanism Could Spark a New Antivenom Strategy

Toxin-inhibiting proteins evolved by rattlesnakes protected mice from lethal venom doses and showed activity against toxins from some other vipers.

Sex-Specific Dioxin Toxicity in a Humanized AHR Model

Sex-Specific Dioxin Toxicity in a Humanized AHR Model

Explore how species-specific aryl hydrocarbon receptor signaling and biological sex influence hepatic responses to environmentally relevant dioxin exposure and inform human health risk assessment.

Alt-Text A conceptual image of blue histograms on a graph gradually increasing in size up toward the right with a trendline following.

Federal Research Grant Awards Fall to a Six-Year Low

An independent grant tracker's analysis of NIH's own award records shows the agency has issued fewer grant awards this fiscal year than in any of the past six.

Multimedia

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Explore how blood-based biomarkers perform across Alzheimer’s disease stages, including AIBL Study findings comparing p-Tau217 and other markers against amyloid-beta and tau PET reference standards.

Three-dimensional illustration of a curved, single-stranded RNA molecule against a blue background

Gene Editing Precision Depends on Guide RNA Quality

Reduce synthesis-related impurities and support target recognition with gRNA purification

The Scientist October Digest cover

October 2026

Antarctica’s Blood Falls Teems With Mysterious Microbial Life

Miles away from the closest ocean, marine microbes thrive in the red ice and mud around Blood Falls, offering clues to microbial adaptation and past climate events.

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Research Resources

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Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Explore how blood-based biomarkers perform across Alzheimer’s disease stages, including AIBL Study findings comparing p-Tau217 and other markers against amyloid-beta and tau PET reference standards.

Find better biologics faster with Stunner and the AI Developability Workcell

Find better biologics faster with Stunner and the AI Developability Workcell

Learn how microvolume UV/Vis and DLS can accelerate, automate, and streamline protein developability screening while reducing sample requirements.

An image of microcentrifuge tubes arranged within colorful laboratory racks.

Choose clarity. Choose speed. Choose MyMass™

Assess protein sample purity and homogeneity in minutes with mass photometry using only nanograms of sample.

Characterizing LNP Heterogeneity With Super-Resolution Imaging

Characterizing LNP Heterogeneity With Super-Resolution Imaging

Explore how super-resolution microscopy enables particle-level characterization of lipid nanoparticle composition, cargo loading, heterogeneity, and stability, providing complementary insights for formulation development and optimization.

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Product News

Stellaromics Expands Pyxa Adoption as Instruments are Installed at Leading Research Institutions Across the U.S. and EuropeStellaromics, Inc., the leader in 3D

The placements follow the commercial launch of Pyxa at the Advances in Genome Biology and Technology (AGBT) meeting in February 2026 and mark the company's transition from Early Access into global commercial availability.

A monoclonal antibody surrounded by immune cells and red blood cells

CellRaft AIR: Find the Right Antibody-Producing Cells Faster

The CellRaft AIR streamlines antibody discovery with imaging, functional screening, and gentle isolation of viable single B cells and hybridomas, helping verify monoclonality and identify high producing clones faster.

Maxwell® Rapid ccfDNA Kit

Maxwell® Rapid ccfDNA Kit: Automated Purification of ccfDNA in Under 30 Minutes

Load plasma directly into prefilled cartridges, no pretreatment, no ethanol. Under 30 minutes of instrument run time, up to 48 samples in parallel, with a high-throughput format also available.

Leica Biosystems, Tempus, and Paige logos side by side, marking the addition of Paige digital pathology AI tools to the Aperio AI Store.

Oncology Researchers Gain AI Cancer Tools in One Platform

Two Paige tools, powered by the Virchow pathology foundation model, are now available within a single image management workspace for oncology research.