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New Screening Approach Reveals Novel Regulators of Microcephaly
New Screening Approach Reveals Novel Regulators of Microcephaly
Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.
New Screening Approach Reveals Novel Regulators of Microcephaly
New Screening Approach Reveals Novel Regulators of Microcephaly

Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.

Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.

extracellular matrix

An image of lung tissue acquired using a MALDI imaging mass spectrometer.
Glycogen Metabolism May Play a Key Role in Pulmonary Fibrosis
Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read
Researchers discover that glycogen and N-linked glycans accumulate in fibrotic regions of the lung and may be important for therapy development.
A microscopy image of an apical-out colon organoid that was produced using MilliporeSigma’s protocol.
Turning Organoids Inside Out 
The Scientist, MilliporeSigma, and Hub Organoids | Aug 15, 2023 | 4 min read
Discover how a new procedure reverses the polarity of typical basolateral-out organoids to form versatile apical-out organoids.
Abstract rendering of a tumor and its microenvironment in purple
The Basics of the Tumor Microenvironment
Johanna Pruller, PhD | Jun 15, 2023 | 4 min read
Learn about the tumor microenvironment (TME), a key influencer of cancer growth, spread, and treatment success.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021 | 2 min read
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
A Better Hydrogel for 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | May 13, 2021 | 2 min read
Drug screening in 3D cell cultures is possible with the right tools.
Technique Talk: High-Throughput Drug Screening Using 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | May 5, 2021 | 1 min read
In this workshop, learn how to use hydrogel 3D cell culture plates for streamlined 3D cell culture colony formation, imaging, metabolic read-out, and T cell-mediated tumor cell killing.
Promoting Stem Cell Growth and Self-Renewal In Vitro
The Scientist Creative Services Team in collaboration with MilliporeSigma | Feb 19, 2021 | 2 min read
An engineered laminin substrate facilitates high-quality human stem cell cultures.
Exploring the Matrix: A Profile of Zena Werb
Diana Kwon | Dec 1, 2019 | 7 min read
The cell and molecular biologist unveiled a role for the breakdown of proteins in the extracellular matrix in both healthy and pathogenic cells.
Image of the Day: Actin Assembly
Emily Makowski | Sep 17, 2019 | 1 min read
Microtubules need actin to disassemble focal adhesions, allowing for cell movement.
Study Explains How Newborn Mice Can Regrow Damaged Hearts
Ruth Williams | May 2, 2018 | 4 min read
The extracellular matrix appears to inhibit regeneration; but scientists debate whether heart muscle really comes back.  
Image of the Day: Reunited and It Feels So Good
The Scientist | Jul 28, 2017 | 1 min read
Zebrafish have a remarkable ability to heal their damaged nerve fibers following a spinal injury.
Location, Location, Location
Anna Azvolinsky | Apr 1, 2017 | 9 min read
Since first proposing that a cell’s function and biology depend on its surroundings, Mina Bissell continues to probe the role of the extracellular matrix.
“Ghost Fibers” Help Heal Muscle Injury
Karen Zusi | Dec 15, 2015 | 1 min read
Injured muscle cells leave behind organized collagen fibers that act as scaffolding for new tissue growth.
Brain Freeze
Kerry Grens | Oct 1, 2015 | 2 min read
A common tissue fixation method distorts the true neuronal landscape.
The Science of Stretch
Helene M. Langevin | May 1, 2013 | 10 min read
The study of connective tissue is shedding light on pain and providing new explanations for alternative medicine.
Pointed Science
Helene M. Langevin | Apr 30, 2013 | 1 min read
University of Vermont neurologist Helene Langevin explains some emerging research attempting to explain the benefits of acupuncture.
The Science of Acupuncture
Helene M. Langevin | Apr 30, 2013 | 1 min read
Research is uncovering connective tissue's role in the benefits of the ancient practice.
(Re)Programming Director
Karen Hopkin | Oct 1, 2012 | 9 min read
Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.
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