New Screening Approach Reveals Novel Regulators of Microcephaly
New Screening Approach Reveals Novel Regulators of Microcephaly
Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.
New Screening Approach Reveals Novel Regulators of Microcephaly
New Screening Approach Reveals Novel Regulators of Microcephaly

Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.

Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.

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extracellular matrix

Exploring the Matrix: A Profile of Zena Werb
Diana Kwon | Dec 1, 2019
The cell and molecular biologist unveiled a role for the breakdown of proteins in the extracellular matrix in both healthy and pathogenic cells.
Image of the Day: Actin Assembly
Emily Makowski | Sep 17, 2019
Microtubules need actin to disassemble focal adhesions, allowing for cell movement.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
Study Explains How Newborn Mice Can Regrow Damaged Hearts
Ruth Williams | May 2, 2018
The extracellular matrix appears to inhibit regeneration; but scientists debate whether heart muscle really comes back.  
Image of the Day: Reunited and It Feels So Good
The Scientist Staff | Jul 28, 2017
Zebrafish have a remarkable ability to heal their damaged nerve fibers following a spinal injury.
A Better Hydrogel for 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | May 13, 2021
Drug screening in 3D cell cultures is possible with the right tools.
Location, Location, Location
Anna Azvolinsky | Apr 1, 2017
Since first proposing that a cell’s function and biology depend on its surroundings, Mina Bissell continues to probe the role of the extracellular matrix.
“Ghost Fibers” Help Heal Muscle Injury
Karen Zusi | Dec 15, 2015
Injured muscle cells leave behind organized collagen fibers that act as scaffolding for new tissue growth.
Technique Talk: High-Throughput Drug Screening Using 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | May 5, 2021
In this workshop, learn how to use hydrogel 3D cell culture plates for streamlined 3D cell culture colony formation, imaging, metabolic read-out, and T cell-mediated tumor cell killing.
Brain Freeze
Kerry Grens | Oct 1, 2015
A common tissue fixation method distorts the true neuronal landscape.
The Science of Stretch
Helene M. Langevin | May 1, 2013
The study of connective tissue is shedding light on pain and providing new explanations for alternative medicine.
Promoting Stem Cell Growth and Self-Renewal In Vitro
The Scientist Creative Services Team in collaboration with MilliporeSigma | Feb 19, 2021
An engineered laminin substrate facilitates high-quality human stem cell cultures.
The Science of Acupuncture
Helene M. Langevin | Apr 30, 2013
Research is uncovering connective tissue's role in the benefits of the ancient practice.
Pointed Science
Helene M. Langevin | Apr 30, 2013
University of Vermont neurologist Helene Langevin explains some emerging research attempting to explain the benefits of acupuncture.
(Re)Programming Director
Karen Hopkin | Oct 1, 2012
Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.