An artist's rendition of an RNA molecule in light blue on a dark blue background
Same RNA Acts in Neurodegeneration and Cancer
The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.
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Same RNA Acts in Neurodegeneration and Cancer
Same RNA Acts in Neurodegeneration and Cancer

The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.

The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.

ABOVE: ISTOCK.COM, LIBRE DE DROIT
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gene regulation

Abstract illustration of DNA
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
A microscopy image of several endometrial stromal fibroblasts
Gene Offers Clue to How Human Labor Starts
Christie Wilcox | Aug 1, 2021
Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.
The Inside Scoop on Successful ATAC-seq Experiments
Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments
The Scientist Creative Services Team | Jan 17, 2022
Discover how to best map a cell’s epigenetic landscape
illustration of multiple clocks arranged in the shape of a brain
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Integrating Single-Cell Transcriptomics and Proteomics: A New Era of Biological Research
Bridging the Gap: Integrating Single-Cell Transcriptomics and Proteomics
The Scientist Creative Services Team in Collaboration with IsoPlexis | Dec 3, 2021
An expert panel will discuss how a functional cell library confirms critical insights from previous omics studies. Additionally, they will introduce an innovative platform that connects single cell transcriptomics with functional proteomics for the first time.
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
model organism, zebrafish, sponge, cell &molecular biology, genetics & genomics, enhancer, transcription, non-coding DNA, gene regulation, evolution
Regulators of Gene Activity in Animals Are Deeply Conserved
Amanda Heidt | Nov 6, 2020
Enhancers, short regions of DNA that direct gene expression, of species separated by 700 million years of evolution worked interchangeably, according to a new study.
Sample Preparation with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist Creative Services Team | Sep 30, 2020
In this webinar brought to you by 10x Genomics, experts will discuss how to successfully prepare nuclei suspensions for Single Cell Multiome ATAC + Gene Expression experiments.
New Map Charts Genetic Expression Across Tissue Types, Sexes
Ashley Yeager | Sep 10, 2020
A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
Getting Started with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist Creative Services Team | Sep 15, 2020
In this webinar brought to you by 10x Genomics, experts will discuss tips for running Chromium Single Cell Multiome ATAC + Gene Expression experiments in your lab.
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020
Scientists identify a transcription factor that plays a key role in increased fruit size.
Salk Institute Cofounder Melvin Cohn Dies
Ashley Yeager | Oct 26, 2018
Cohn was a leader in gene regulation and immune system research and left a lasting legacy in La Jolla.
Uncovering Functions of Circular RNAs
Catherine Offord | Jul 16, 2017
Recent research has revealed many surprises about circular RNAs, from findings that they are translated in vivo to links between their expression and disease.
Wanted: Transcriptional Regulators
Ruth Williams | Aug 1, 2016
Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.
Riboswitch Screen
Ruth Williams | Jul 31, 2016
A newly developed method detects regulators of bacterial transcription called riboswitches.
RNA Methylation Dynamics
and Gidi Rechavi, Dan Dominissini, Chuan He | Dec 31, 2015
Additions to the bases of RNA molecules can be written, read, and erased.
Metazoans in the DNAi Club
Amanda B. Keener | Jul 1, 2015
A chance discovery results in the first report of DNA-based gene silencing in an animal.