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gene regulation

Epigenetics May Remember Ancestors’ Mutations

Holly Barker, PhD | Dec 1, 2022 | 4 min read

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

Blue 3D illustration of X-shaped chromosomes

X Chromosome Silenced in Some Cancers in Males

Natalia Mesa, PhD | Nov 11, 2022 | 3 min read

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males.

The Scientist's Journal Club: Transcriptomics

The Scientist’s Creative Services Team | 2 min read

Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.

Ribonucleic acid strands consisting of nucleotides important for protein bio-synthesis

Katharina Höfer Probes the Machinery of Bacterial Gene Expression

Hannah Thomasy, PhD, Drug Discovery News | Jun 13, 2022 | 3 min read

The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.

An artist's rendition of an RNA molecule in light blue on a dark blue background

Same RNA Acts in Neurodegeneration and Cancer

Abby Olena, PhD | Oct 29, 2021 | 3 min read

The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.

Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments

The Scientist’s Creative Services Team | 1 min read

Discover how to best map a cell’s epigenetic landscape

Signaling Dynamics Fine-Tune Gene Expression

Ruth Williams | Sep 3, 2021 | 3 min read

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

A microscopy image of several endometrial stromal fibroblasts

Gene Offers Clue to How Human Labor Starts

Christie Wilcox, PhD | Aug 1, 2021 | 2 min read

Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.

Integrating Single-Cell Transcriptomics and Proteomics: A New Era of Biological Research

Bridging the Gap: Integrating Single-Cell Transcriptomics and Proteomics

The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read

An expert panel will discuss how a functional cell library confirms critical insights from previous omics studies. Additionally, they will introduce an innovative platform that connects single cell transcriptomics with functional proteomics for the first time.

illustration of multiple clocks arranged in the shape of a brain

How Early-Morning Light Exposure Makes Mice Less Depressed

Bianca Nogrady | Jul 22, 2021 | 4 min read

A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.

Cancer May Be Driven by DNA Outside of Chromosomes

Paul Mischel | Apr 1, 2021 | 10+ min read

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

Sample Preparation with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell

The Scientist’s Creative Services Team | 1 min read

In this webinar brought to you by 10x Genomics, experts will discuss how to successfully prepare nuclei suspensions for Single Cell Multiome ATAC + Gene Expression experiments.

Infographic: The Role of Extrachromosomal DNA in Cancer

Paul Mischel | Apr 1, 2021 | 2 min read

Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.

model organism, zebrafish, sponge, cell &molecular biology, genetics & genomics, enhancer, transcription, non-coding DNA, gene regulation, evolution

Regulators of Gene Activity in Animals Are Deeply Conserved

Amanda Heidt | Nov 6, 2020 | 5 min read

Enhancers, short regions of DNA that direct gene expression, of species separated by 700 million years of evolution worked interchangeably, according to a new study.

Getting Started with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell

The Scientist’s Creative Services Team | 1 min read

In this webinar brought to you by 10x Genomics, experts will discuss tips for running Chromium Single Cell Multiome ATAC + Gene Expression experiments in your lab.

New Map Charts Genetic Expression Across Tissue Types, Sexes

Ashley Yeager | Sep 10, 2020 | 3 min read

A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.