Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

gene regulation
Gene Offers Clue to How Human Labor Starts
Gene Offers Clue to How Human Labor Starts
Christie Wilcox | Aug 1, 2021
Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.
How Early-Morning Light Exposure Makes Mice Less Depressed
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Infographic: The Role of Extrachromosomal DNA in Cancer
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
Regulators of Gene Activity in Animals Are Deeply Conserved
Regulators of Gene Activity in Animals Are Deeply Conserved
Amanda Heidt | Nov 6, 2020
Enhancers, short regions of DNA that direct gene expression, of species separated by 700 million years of evolution worked interchangeably, according to a new study.
New Map Charts Genetic Expression Across Tissue Types, Sexes
New Map Charts Genetic Expression Across Tissue Types, Sexes
Ashley Yeager | Sep 10, 2020
A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.
Cracking Down on Cancer: A Profile of Owen Witte
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
Image of the Day: Tomato Domestication
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020
Scientists identify a transcription factor that plays a key role in increased fruit size.
Salk Institute Cofounder Melvin Cohn Dies
Salk Institute Cofounder Melvin Cohn Dies
Ashley Yeager | Oct 26, 2018
Cohn was a leader in gene regulation and immune system research and left a lasting legacy in La Jolla.
Uncovering Functions of Circular RNAs
Uncovering Functions of Circular RNAs
Catherine Offord | Jul 16, 2017
Recent research has revealed many surprises about circular RNAs, from findings that they are translated in vivo to links between their expression and disease.
Wanted: Transcriptional Regulators
Wanted: Transcriptional Regulators
Ruth Williams | Aug 1, 2016
Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.
Riboswitch Screen
Riboswitch Screen
Ruth Williams | Jul 31, 2016
A newly developed method detects regulators of bacterial transcription called riboswitches.
RNA Methylation Dynamics
RNA Methylation Dynamics
and Gidi Rechavi, Dan Dominissini, Chuan He | Dec 31, 2015
Additions to the bases of RNA molecules can be written, read, and erased.
Metazoans in the DNAi Club
Metazoans in the DNAi Club
Amanda B. Keener | Jul 1, 2015
A chance discovery results in the first report of DNA-based gene silencing in an animal.
Silencing Surprise
Silencing Surprise
Jenny Rood | Jun 1, 2015
A chromatin remodeler in embryonic stem cells clears the DNA for mRNA transcription while stifling the expression of noncoding transcripts.
Exploring the Impacts of Genetic Variation on Tissue-Specific Expression
Exploring the Impacts of Genetic Variation on Tissue-Specific Expression
Jenny Rood | May 7, 2015
Preliminary results from the Genotype-Tissue Expression project reveal that gene expression varies more across tissues than across individuals.
Rethinking Telomeres
Rethinking Telomeres
Kate Yandell | Mar 1, 2015
Not only do telomeres protect the ends of chromosomes, they also modulate gene expression over cells’ lifetimes.