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Artist’s rendition of a blue-green DNA double helix, viewed lengthwise from within one end.
Stem Cell Lines Riddled With Undetected Mutations
Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.
Stem Cell Lines Riddled With Undetected Mutations
Stem Cell Lines Riddled With Undetected Mutations

Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.

Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.

iPSCs
a mockup of an at-home COVID-19 test in development
Top Technical Advances of 2020
Shawna Williams | Dec 18, 2020 | 3 min read
The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019 | 3 min read
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
3D medical illustration of peripheral blood cells: a lymphocyte (left) and a monocyte (right) surrounded by red blood cells.
PBMCs: Mononucleated and Multipurposed
Deanna MacNeil, PhD | 4 min read
Researchers employ peripheral blood mononuclear cells (PBMCs) in clinical and academic applications related to the immune system and regenerative medicine.
Lindsay Hanford, Geoff B Hall
Trial Launched to Treat Parkinson’s with Reprogrammed Stem Cells
Diana Kwon | Jul 31, 2018 | 1 min read
Surgeons will inject approximately 5 million dopamine-producing progenitor cells into patients’ brains.
Vision Restored: The Latest Technologies to Improve Sight
Anna Azvolinsky | Apr 10, 2018 | 5 min read
Cell implants, gene therapy, even optogenetics are making headway in clinical trials to treat various forms of blindness.  
Key Strategies for Better Stem Cell Workflows
Solutions for Optimizing Stem Cell Therapy Development
Sartorius | 1 min read
Discover how process knowledge is integral to stem cell workflow improvement and optimization.
Researchers Make Knockout Stem Cell Lines in One Step
Ruth Williams | Dec 1, 2017 | 3 min read
Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.
Infographic: Combo Method of Stem Cell Generation
Ruth Williams | Nov 30, 2017 | 1 min read
Simultaneous exposure to reprogramming and gene-editing plasmids efficiently produces edited pluripotent colonies.
Learn about innovations in tissue regeneration 
Stem Cell Engineering for Tissue Regeneration
The Scientist Creative Services Team | 1 min read
Innovative strategies drive stem cell repair of organ damage.
Suicide Switch for Transplanted Stem Cells
Abby Olena, PhD | Mar 2, 2017 | 3 min read
Researchers use an inducible gene to limit tumor growth from human iPSCs transplanted into mice.
Week in Review: October 17–21
Jef Akst | Oct 20, 2016 | 2 min read
Report finds that pathologist involved in anonymous defamation case committed multiple acts of misconduct; growing eggs from stem cells; neutrophils’ role in metastasis; convergent evolution in birds
A Brief History of Stem Cells
Scientific Breakthroughs with Stem Cells
Nele Haelterman, PhD | 1 min read
Discover the various ways scientists bolster stem cells to understand and cure disease.
Stem Cells Made Waves in Biology and Medicine
Karen Zusi | Oct 1, 2016 | 6 min read
Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.
Thirty Years of Progress
The Scientist Staff | Oct 1, 2016 | 1 min read
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
The Scientist Speaks - Modeling Epilepsy in a Dish Using Patient-Derived iPSCs
Sejal Davla, PhD | 1 min read
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Kelly Rae Chi | Sep 1, 2016 | 8 min read
Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.
Review: The End of Sex
Tanya Lewis | May 13, 2016 | 2 min read
Legal expert Henry Greely envisions a world in which advances in biotechnology obviate the need for sexual reproduction as we know it.
800x560-nov-23-2021
A Guide for High-Throughput Screens with Pluripotent Stem Cells
The Scientist Creative Services Team in collaboration with Miltenyi Biotec | 1 min read
Experts discuss reliable high-throughput workflows for PSC-derived cellular screens
Skin Cells Turned Into Immature Sperm
Tanya Lewis | Apr 29, 2016 | 1 min read
The reprogrammed germ-like cells were unable to fertilize eggs, however. 
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