Top Technical Advances of 2020
Top Technical Advances of 2020
The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.
Top Technical Advances of 2020
Top Technical Advances of 2020

The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.

The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.

iPSCs
Sergiu Pasca Builds Brains to Study Developmental Disease
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
Trial Launched to Treat Parkinson’s with Reprogrammed Stem Cells
Trial Launched to Treat Parkinson’s with Reprogrammed Stem Cells
Diana Kwon | Jul 31, 2018
Surgeons will inject approximately 5 million dopamine-producing progenitor cells into patients’ brains.
Vision Restored: The Latest Technologies to Improve Sight
Vision Restored: The Latest Technologies to Improve Sight
Anna Azvolinsky | Apr 10, 2018
Cell implants, gene therapy, even optogenetics are making headway in clinical trials to treat various forms of blindness.  
Researchers Make Knockout Stem Cell Lines in One Step
Researchers Make Knockout Stem Cell Lines in One Step
Ruth Williams | Dec 1, 2017
Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.
Infographic: Combo Method of Stem Cell Generation
Infographic: Combo Method of Stem Cell Generation
Ruth Williams | Nov 30, 2017
Simultaneous exposure to reprogramming and gene-editing plasmids efficiently produces edited pluripotent colonies.
Suicide Switch for Transplanted Stem Cells
Suicide Switch for Transplanted Stem Cells
Abby Olena | Mar 2, 2017
Researchers use an inducible gene to limit tumor growth from human iPSCs transplanted into mice.
Week in Review: October 17–21
Week in Review: October 17–21
Jef Akst | Oct 20, 2016
Report finds that pathologist involved in anonymous defamation case committed multiple acts of misconduct; growing eggs from stem cells; neutrophils’ role in metastasis; convergent evolution in birds
Thirty Years of Progress
Thirty Years of Progress
The Scientist Staff | Oct 1, 2016
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.
Stem Cells Made Waves in Biology and Medicine
Stem Cells Made Waves in Biology and Medicine
Karen Zusi | Oct 1, 2016
Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Kelly Rae Chi | Sep 1, 2016
Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.
Review: <em>The End of Sex</em>
Review: The End of Sex
Tanya Lewis | May 13, 2016
Legal expert Henry Greely envisions a world in which advances in biotechnology obviate the need for sexual reproduction as we know it.
Skin Cells Turned Into Immature Sperm
Skin Cells Turned Into Immature Sperm
Tanya Lewis | Apr 29, 2016
The reprogrammed germ-like cells were unable to fertilize eggs, however. 
Monitoring Mitochondrial Mutations
Monitoring Mitochondrial Mutations
Catherine Offord | Apr 17, 2016
Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.
Zika Seeks, Destroys Developing Neurons
Zika Seeks, Destroys Developing Neurons
Tanya Lewis | Apr 11, 2016
The virus infects and kills human neural stem cells and impedes brain tissue development, according to a study.
Hairy Skin from Stem Cells
Hairy Skin from Stem Cells
Tanya Lewis | Apr 5, 2016
Researchers create lab-grown mouse skin complete with hair follicles and sweat glands.
Hairy Skin from Stem Cells
Tanya Lewis | Apr 4, 2016
Researchers create lab-grown mouse skin complete with hair follicles and sweat glands.