An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left).
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Amyloid Precursor Protein Linked to Brain Development Mechanisms

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

membrane proteins
M. Mueckler looking at the camera in front of his microscope in 1998.
Cellular Biologist Michael Mueckler Dies at 67
Lisa Winter | Aug 18, 2021
His work centered on the mechanisms of glucose transport into cells.
amoeba Entamoeba histolytica trogocytosis human cell surface protein
Image of the Day: Amoeba Nibbles
Chia-Yi Hou | May 2, 2019
A pathogenic amoeba species ingests parts of human cells and steals human cell membrane proteins to display on its own surface.
Measuring Membrane Proteins with Mass-Sensitive Particle Tracking
The Scientist Creative Services Team in collaboration with Refeyn
Researchers will discuss a new mass photometry method that characterizes molecules in their native state on supported lipid bilayers.
New Technologies Shed Light on Caveolae
Ben Nichols | Jun 1, 2018
The functions of the cellular invaginations identified more than half a century ago are now beginning to be understood in detail.
Infographic: Caveolae Form and Function
Ben Nichols | May 31, 2018
Researchers interrogate the cavernous structures on the surface of cells to better understand how they affect membrane function.
Identifying Antibodies that Target Membrane Proteins in Their Native Conformations
The Scientist Creative Services Team in collaboration with OXGENE
A new mammalian display platform enhances antibody discovery for challenging protein targets.
Researchers Produce Alpaca Antibodies Using Yeast
Catherine Offord | Feb 13, 2018
With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca or one of its relatives.
Image of the Day: Membrane FeverĀ 
The Scientist Staff and The Scientist Staff | Nov 17, 2017
Scientists have discovered a mechanism by which the Rift Valley fever virus infects the cells of its hosts.
Pushing Boundaries
Anna Azvolinsky | Dec 1, 2016
Applying physics, chemistry, and cell biology, Satyajit Mayor seeks to understand how cell membranes work.
Video: Cells, Skin Deep
The Scientist Staff | Nov 30, 2016
Profilee Satyajit Mayor discusses his explorations of cell membranes, which are helping to update the classical fluid mosaic model of dynamic cellular boundaries.
Crystal Structure, Murky Function
Ruth Williams | Jan 29, 2015
Scientists have determined the crystal structures of bacterial translocator proteins, but their functions remain unclear.
Key Osmotic Channel Protein Identified
Rina Shaikh-Lesko | Apr 10, 2014
A little-studied protein appears to be a critical part of the perplexing channel that prevents cells from bursting.
Protein Zippers
Jef Akst | Jun 1, 2013
Matching up positive and negative charges on two of its subunits may allow the TatA membrane transporter to penetrate the lipid bilayer.
Synthetic Peptide Fools Immune System
Dan Cossins | Feb 21, 2013
Researchers have created a molecule that helps nanoparticles evade immune attack and could improve drug delivery.
 
Plant RNAs Found in Mammals
Cristina Luiggi | Sep 20, 2011
MicroRNAs from plants accumulate in mammalian blood and tissues, where they can regulate gene expression.
How Vampire Bats Find Veins
Jessica P. Johnson | Aug 4, 2011
Heat-sensing protein channels in vampire bats allow the flying mammals to find the best place to sink their teeth into their prey.
String Theory
Richard P. Grant | Aug 1, 2011
New types of biological filaments are turning up in yeast, fly, bacterial cells and in rat neurons, and they may yield clues to how the cytoskeleton evolved from metabolically active enzymes.
The Birth of Optogenetics
Edward S. Boyden | Jul 1, 2011
An account of the path to realizing tools for controlling brain circuits with light.
OPSINS: Tools of the trade
Edward S. Boyden | Jul 1, 2011
The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light.