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An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left).
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Amyloid Precursor Protein Linked to Brain Development Mechanisms

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.

membrane proteins
M. Mueckler looking at the camera in front of his microscope in 1998.
Cellular Biologist Michael Mueckler Dies at 67
Lisa Winter | Aug 18, 2021 | 1 min read
His work centered on the mechanisms of glucose transport into cells.
amoeba Entamoeba histolytica trogocytosis human cell surface protein
Image of the Day: Amoeba Nibbles
Chia-Yi Hou | May 2, 2019 | 1 min read
A pathogenic amoeba species ingests parts of human cells and steals human cell membrane proteins to display on its own surface.
Streamlining Membrane Protein Research with Mass Photometry
Streamlining Membrane Protein Research with Mass Photometry
The Scientist’s Creative Services Team and Refeyn | 3 min read
Mass photometry advances membrane protein characterization by offering fast and precise mass measurements of samples containing membrane mimetics. 
New Technologies Shed Light on Caveolae
Ben Nichols | Jun 1, 2018 | 10+ min read
The functions of the cellular invaginations identified more than half a century ago are now beginning to be understood in detail.
Infographic: Caveolae Form and Function
Ben Nichols | May 31, 2018 | 1 min read
Researchers interrogate the cavernous structures on the surface of cells to better understand how they affect membrane function.
Measuring Membrane Proteins with Mass-Sensitive Particle Tracking
The Scientist Creative Services Team in collaboration with Refeyn | 2 min read
Researchers will discuss a new mass photometry method that characterizes molecules in their native state on supported lipid bilayers.
Researchers Produce Alpaca Antibodies Using Yeast
Catherine Offord | Feb 13, 2018 | 2 min read
With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca or one of its relatives.
Image of the Day: Membrane Fever 
The Scientist Staff and The Scientist Staff | Nov 17, 2017 | 1 min read
Scientists have discovered a mechanism by which the Rift Valley fever virus infects the cells of its hosts.
Identifying Antibodies that Target Membrane Proteins in Their Native Conformations
The Scientist Creative Services Team in collaboration with OXGENE | 2 min read
A new mammalian display platform enhances antibody discovery for challenging protein targets.
Pushing Boundaries
Anna Azvolinsky | Dec 1, 2016 | 8 min read
Applying physics, chemistry, and cell biology, Satyajit Mayor seeks to understand how cell membranes work.
Video: Cells, Skin Deep
The Scientist Staff | Nov 30, 2016 | 1 min read
Profilee Satyajit Mayor discusses his explorations of cell membranes, which are helping to update the classical fluid mosaic model of dynamic cellular boundaries.
Crystal Structure, Murky Function
Ruth Williams | Jan 29, 2015 | 3 min read
Scientists have determined the crystal structures of bacterial translocator proteins, but their functions remain unclear.
Key Osmotic Channel Protein Identified
Rina Shaikh-Lesko | Apr 10, 2014 | 3 min read
A little-studied protein appears to be a critical part of the perplexing channel that prevents cells from bursting.
Protein Zippers
Jef Akst | Jun 1, 2013 | 2 min read
Matching up positive and negative charges on two of its subunits may allow the TatA membrane transporter to penetrate the lipid bilayer.
Synthetic Peptide Fools Immune System
Dan Cossins | Feb 21, 2013 | 3 min read
Researchers have created a molecule that helps nanoparticles evade immune attack and could improve drug delivery.
 
Plant RNAs Found in Mammals
Cristina Luiggi | Sep 20, 2011 | 3 min read
MicroRNAs from plants accumulate in mammalian blood and tissues, where they can regulate gene expression.
How Vampire Bats Find Veins
Jessica P. Johnson | Aug 4, 2011 | 3 min read
Heat-sensing protein channels in vampire bats allow the flying mammals to find the best place to sink their teeth into their prey.
String Theory
Richard P. Grant | Aug 1, 2011 | 3 min read
New types of biological filaments are turning up in yeast, fly, bacterial cells and in rat neurons, and they may yield clues to how the cytoskeleton evolved from metabolically active enzymes.
The Birth of Optogenetics
Edward S. Boyden | Jul 1, 2011 | 10+ min read
An account of the path to realizing tools for controlling brain circuits with light.
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