A photograph of Christine Guthrie with former students James Umen and Hiten Madhani
RNA Pioneer Christine Guthrie Dies at 77
Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.
RNA Pioneer Christine Guthrie Dies at 77
RNA Pioneer Christine Guthrie Dies at 77

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

mRNA
3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background
Cancers Ramp Up Overall mRNA Expression as They Progress
Dan Robitzski | Jun 14, 2022
A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.
illustration of a large purple molecular complex with a strand of orange RNA running through it and red strand emerging from it
Study Reveals Outsize Role of mRNA Region in Tuning Expression
Sophie Fessl | Jan 27, 2022
A new method helps researchers uncover the rules of ribosome recruitment in yeast.
COVID-19 vaccine vials
COVID-19 Vaccines Induce Better Long-Term Immunity than Infection
Jennifer Zieba, PhD
For the first time, researchers performed a head-to head longitudinal study comparing the immune response elicited by mRNA and traditional COVID-19 vaccines to primary infections.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl | Jan 6, 2022
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
Isolated Realistic Coronavirus Covid-19 Molecule in a Biological Environment stock photo
Tweak to N Protein Makes Delta Variant More Infectious
Chloe Tenn | Nov 5, 2021
Using a novel lab technique, researchers identified a mutation that allows the virus to insert more genetic material into host cells.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist Creative Services Team and Mirus Bio
A high efficiency, low toxicity method for direct RNA delivery into cells.
cartoon image showing colorful collection of syringes, coronavirus particles, and mrna to represent the vaccine development
Optogenetics and mRNA Vaccines Net Lasker Awards
Annie Melchor | Sep 24, 2021
This year’s winners are Dieter Oesterhelt, Peter Hegemann, Karl Deisseroth, Drew Weissman, Katalin Karikó, and David Baltimore.
Woman holding a CDC COVID-19 vaccination card with both hands.
COVID-19 mRNA Vaccines Appear Effective Against Multiple Variants
Lisa Winter | May 6, 2021
Data from three studies indicate that fully vaccinated patients are able to stave off severe disease from the B.1.1.7, B.1.351, and P.1 variants.
The Scientist Speaks - Thieves on the Inside: Viral Control of Host Gene Expression
Niki Spahich, PhD
Britt Glaunsinger discusses how viruses steal from their hosts to take over cellular processes and promote their own survival.
pregnancy pregnant covid-19 coronavirus pandemic sars-cov-2 vaccine immunization moderna mrna pfizer/biontech
COVID-19 Vaccines Appear Safe During Pregnancy: Early Data
Christie Wilcox | Apr 22, 2021
Scientists at the US CDC report no red flags in a preliminary analysis of the safety of Pfizer/BioNTech’s and Moderna’s mRNA-based immunizations among expectant mothers.
Scientists Reverse Engineer mRNA Sequence of Moderna Vaccine
Lisa Winter | Apr 6, 2021
Stanford University researchers determined the code from spare drops in discarded vials of the COVID-19 vaccine and published it on GitHub.
COVID-19, SARS-CoV-2, coronavirus, pandemic, vaccine, vaccine trials, combination, mix and match, immunity, antibodies, T cells, Pfizer, Moderna, AstraZeneca, clinical trials
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
2021 life science predictions innovations biotech mrna single-cell sequencing diagnostics
Experts Predict the Hottest Life Science Tech in 2021 and Beyond
Bob Grant | Feb 1, 2021
Last year’s Top 10 Innovations judges look into their crystal balls.
How RNAs Called SINEUPs Upregulate Translation
Catherine Offord | Jan 1, 2021
The recently discovered long noncoding RNAs seem to boost the production of specific proteins in the cell by interacting with RNA-binding proteins, researchers find.
a mockup of an at-home COVID-19 test in development
Top Technical Advances of 2020
Shawna Williams | Dec 18, 2020
The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.
mrna vaccine covid-19 astrazeneca pfizer biontech moderna coronavirus pandemic sars-cov-2 spike protein
The Promise of mRNA Vaccines
Diana Kwon | Nov 25, 2020
Long before Moderna’s and Pfizer’s COVID-19 shots, scientists had been considering the use of genetically encoded vaccines in the fight against infectious diseases, cancer, and more.
Moderna’s COVID-19 Vaccine 94 Percent Effective: Initial Data
Max Kozlov | Nov 16, 2020
The results mark the second experimental COVID-19 vaccine to show high efficacy, but the study is not complete and the data have not been peer reviewed.
SARS-CoV-2 Disables Key Components of Human Cells’ Defense System
Catherine Offord | Oct 22, 2020
Researchers detail how viral proteins interact with host RNA to disrupt the cell’s ability to fight back against infection.
Infographic: How Splicing of Genes Can Affect Heart Health
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020
The way in which mRNA transcripts are cut can influence the elasticity of the organ.