Scientist hunched over a lab workbench in exhaustion
Neurotransmitter Buildup May Be Why Your Brain Feels Tired
Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.
Neurotransmitter Buildup May Be Why Your Brain Feels Tired
Neurotransmitter Buildup May Be Why Your Brain Feels Tired

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

neurobiology
illustration of brain with DNA strand coming out the top
Genetic Underpinnings of Brain Activity May Differ in Autism
Emily Harris, Spectrum | Jul 19, 2022
A study finds that expression levels of certain genes that track with brain activity—particularly those involved in brain development—vary between people with autism and their non-autistic peers.
Photo of Ana Marija Jakšic
Ana Marija Jakšić Shapes Fruit Fly Brains
Chloe Tenn | Apr 18, 2022
The Swiss Federal Institute of Technology Lausanne evolutionary neurobiologist is using Drosophila to investigate how organisms adapt to novel environments.
40422-lt-highqualityscreening-800x560
High-Quality Screening and Target Validation During Drug Development
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific
Drew Adams will discuss his work developing therapeutics that promote remyelination for neurological diseases.
Tiled blue-gray MRI readouts of a human brain.
Cancer Tied to Reduced Risk of Alzheimer’s Disease
Dan Robitzski | Apr 14, 2022
Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.
An illustration showing a scale weighing two double-stranded pieces of DNA that has a big question mark in the center.
Mouse Foraging Behavior Shaped by Opposite-Sex Parent’s Genes
Dan Robitzski | Apr 12, 2022
A study in mice finds that for certain genes, one parent’s allele can dominate expression and shape behavior—and which parent’s allele does so varies throughout the body.
The Scientist Speaks Podcast - Episode 1
The Scientist Creative Services Team
Birds on the Brain: The Neuroscience Behind Songbird Communication and Human Speech
Older woman with hat and pink blouse smiling at camera.
Anne Beaumanoir, Activist and Clinical Neurologist, Dies at 98
Natalia Mesa | Mar 29, 2022
Beaumanoir helped Jews evade Nazis during World War II and aided resistance fighters during the Algerian War of Independence. She also contributed to the field of epileptology.
Histological stain of motor neurons in purple and green
Researchers Use Ultrasound to Control Neurons in Mice
Natalia Mesa | Feb 9, 2022
A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.
Artist’s rendering of brain fog: a bright blue drawing of a brain sits inside of a pink drawing of a head in profile surrounded by miscellaneous shapes
Brain Fog Caused by Long COVID and Chemo Appear Similar
Dan Robitzski | Jan 28, 2022
Data from mouse models for mild coronavirus infections and human tissue samples offer further evidence that it doesn’t take a severe infection—or even infection of brain cells at all—to cause long-term neurological symptoms.
Neuro collage
Our Favorite Neuroscience Stories of 2021
Chloe Tenn | Dec 29, 2021
From a Nobel prize and photosynthesis-powered brains to neurodegeneration research and controversy over a new Alzheimer’s drug, a look back at some of the biggest brain-related developments of the year.
illustration of multiple clocks arranged in the shape of a brain
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
illustration of brain cells in blue with amyloid plaques in orange and pink immune cells
Excerpt from The Memory Thief
Lauren Aguirre | Jun 1, 2021
Author Lauren Aguirre finds reasons for optimism in the fight against Alzheimer’s disease.
rugby, concussion, brain injury, concussion, trauma, saliva, spit, test, noninvasive, diagnostic, microRNA, small noncoding RNA, PCR, RNA
Simple Spit Test Could Diagnose Concussions
Asher Jones | Mar 24, 2021
A noninvasive saliva test accurately identified concussions in a study of hundreds of rugby players.
Infographic: A New Model of Synapse Strength
Asher Jones | Mar 24, 2021
Synapses in the mouse neocortex can release multiple packages of neurotransmitters, suggesting that connection strength is more flexible than previously thought.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
dave david schubert salk institute neurobiology cell lines alzheimer's disease curcumin j147 fisetin
Neurobiologist Dave Schubert Dies
Kerry Grens | Aug 24, 2020
The Salk professor developed the institute’s first neurobiology lab and used it to develop cell lines, describe amyloid β toxicity, and screen for compounds that protect against neurodegeneration.
Mark Konishi, Pioneer of Studying Behavior’s Neural Basis, Dies
Ashley Yeager | Aug 14, 2020
The Caltech scientist was revered for his work on the neurobiology of birdsong and owls’ ability to home in on their prey.
Researchers Make Mice Smell Odors that Aren’t Really There
Ruth Williams | Jun 18, 2020
Using optogenetics, scientists have simulated the sense of smell directly within the mouse brain to investigate the nature of olfactory perception.