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“Public” T-Cell Receptors From Resistant People Fend Off HIV
Shawna Williams | Jun 8, 2018
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.
Genetic Adaptation to Cold Brought Migraines With It
Viviane Callier | May 3, 2018
Humans living in higher latitudes tend to have a variant of a gene involved in sensing cold temperatures, but it comes with a cost.
Immune System Targets Diverse Viruses Using the Same Small Peptide
Catherine Offord | Dec 1, 2017
A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related pathogens.
How Poison Frogs Avoid Poisoning Themselves
Abby Olena | Sep 21, 2017
Amphibians resist their own chemical defenses with amino acid modifications in the sequence for a target receptor.
How Immune Receptors Got into Mouse Noses
Shawna Williams | Sep 1, 2017
A study traces proteins’ evolution from the immune to the olfactory system.
Chemogenetics Doesn’t Work Like Many Thought
Kerry Grens | Aug 4, 2017
A study finds the so-called DREADD method of manipulating neurons using a drug called CNO actually works via clozapine.
Endocannabinoids in the Groove
Megan Scudellari | Jul 16, 2017
The system responsible for the buzz humans get from marijuana plays a passel of physiological roles outside the brain.
Molecular Trigger for Organ Rejection in Mice Identified
Diana Kwon | Jun 27, 2017
The cell-surface receptor, SIRP-alpha, initiates the innate immune response in hosts.
Deep Pocket Exploration
Ruth Williams | Feb 1, 2017
A modification to traditional docking software enables the examination of a ligand’s passage into its receptor.
Infographic: Modeling Molecules’ Receptor Binding
Ruth Williams | Jan 31, 2017
A software upgrade follows ligands step-wise into their binding sites on receptors.