How K2 and Other Synthetic Cannabinoids Got Their Start in the Lab

Originally intended for basic neuroscience research, the drugs were ultimately hijacked for illicit recreational use.

Written byAshley Yeager
| 7 min read

Register for free to listen to this article
Listen with Speechify
0:00
7:00
Share

ABOVE: NELLIS AIR FORCE BASE, TECH. SGT. MICHAEL R. HOLZWORTH

About a decade ago, Clemson University chemist John Huffman started getting calls from law enforcement agencies. Officials from the Drug Enforcement Administration (DEA) and other federal agencies wanted to know more about JWH-18, a synthetic cannabinoid bearing Huffman’s initials that he’d created in the lab in 2004 and described in scientific paper in 2005. The compound was turning up in incense, which, rather than being burnt for its scent, was being smoked and was making people sick.

Huffman’s intent, like other scientists who had generated synthetic cannabinoids over the years, was not to create recreational drugs. It was to study the effects of cannabis in the body and how the cannabinoid system works, as well as to develop molecules to image areas of the brain. “The chemistry to make these things is very simple and very old,” Huffman told The ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo