T cell receptor

From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.

Christopher Klebanoff hopes that his search for a small fraction of cancer-specific antigens will have a big impact on cancer cell therapies.

New research revealed hundreds of lipid antigens that may be recognized by adaptive immune T cells.

Immune receptor repertoire profiling is an important analytic tool for disease research in many areas, including cancer, cell and organ transplantation, autoimmunity, and infectious disease. 

By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.

Havran described gamma-delta T cells’ direct function in epithelial repair.

The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.

Human naive T cells are far more heterogeneous than has long been appreciated, having implications for vaccine strategies.

Neoantigens may serve as valuable targets for new immunotherapies.