transcription factors

A protein duo increases transcription of growth-related genes to enhance axon regeneration and boost plasticity, a study finds—but fails to improve mobility.

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

The transcription factor can also drive the opposite transition depending on which hormone activates it, according to a new study.

Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.

The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

Scientists identify a transcription factor that plays a key role in increased fruit size.

Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.

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A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.

A single transcription factor regulates a harlequin ladybird’s colors.

A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.

Using different combinations of transcription factors, researchers create a diverse array of neurons from mouse skin cells.

Researchers stumbled across the connection while searching for ways to reduce vision problems in people with achromatopsia.

A new algorithm scrutinizes the most hard-to-read segments of the genome.

Pauses may help cells fine-tune gene expression.

Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.

Engineered circuits detect endogenous transcription factors to drive cellular outputs.

Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.