Giannina Descalzi
Giannina Descalzi Studies the Factors Underlying Chronic Pain
The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.
Giannina Descalzi Studies the Factors Underlying Chronic Pain
Giannina Descalzi Studies the Factors Underlying Chronic Pain

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

transcription factors
A black and brown ant stands over various sizes of whitish purple, oval shaped larvae and yellow, oblong eggs
A Single Transcription Factor Changes Ants to Queens
Abby Olena | Nov 5, 2021
The transcription factor can also drive the opposite transition depending on which hormone activates it, according to a new study.
Conceptual image of gene expression in DNA
Enhancers: Conserved in Activity, Not in Sequence
Jack J. Lee | Nov 1, 2021
Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Ashley Yeager | Dec 16, 2020
The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  
Genetic Reprogramming Restores Vision in Mice: Study
Max Kozlov | Dec 6, 2020
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020
Scientists identify a transcription factor that plays a key role in increased fruit size.
oct4 yamanaka factor oskm ips ipsc induced pluripotent stem cell
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Emma Yasinski | Nov 8, 2019
Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
Caught on Camera
The Scientist Staff | Oct 1, 2018
Selected Images of the Day from the-scientist.com
Image of the Day: Switch Gears
Sukanya Charuchandra | Sep 10, 2018
A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.
Image of the Day: Kaleidoscope
Sukanya Charuchandra | Aug 27, 2018
A single transcription factor regulates a harlequin ladybird’s colors.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Image of the Day: Cooking Up Neurons
The Scientist Staff and The Scientist Staff | May 11, 2018
Using different combinations of transcription factors, researchers create a diverse array of neurons from mouse skin cells.
Colorblindness Study Reveals Unexpected Way to Make Blood Vessels
Ashley Yeager | May 1, 2018
Researchers stumbled across the connection while searching for ways to reduce vision problems in people with achromatopsia.
Image of the Day: Gene Expression
The Scientist Staff and The Scientist Staff | Apr 9, 2018
A new algorithm scrutinizes the most hard-to-read segments of the genome.
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017
Pauses may help cells fine-tune gene expression.
Bacterial Protein Acts as Prion in Yeast and E. coli
Jef Akst | Jan 16, 2017
Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.
Synthetic Sensors
Ruth Williams | Dec 1, 2016
Engineered circuits detect endogenous transcription factors to drive cellular outputs.
Infographic: How to Build a Synthetic Sensor
Ruth Williams | Nov 30, 2016
Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.
How These Rodents Got Their Stripes
Ashley P. Taylor | Nov 2, 2016
The African striped mouse and the chipmunk develop dorsal stripes through a newly identified mechanism of coat color variation.
With CRISPR, Scientists Make Neurons From Fibroblasts
Kerry Grens | Aug 15, 2016
Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.