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The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.

transcription factors

Front view of a blue and red brain animation with a blue background.

One Gene with a Domino Effect on Social Behavior

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The Oligo Was a No Go

A drawing of the sun on the sand, surrounded by items that people use to protect themselves from UV damage, including sunscreen, a hat, and sunglasses.

Taking Snapshots of DNA Damage in Skin Cancer

A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.

Methylation in Young Brains May Be Key to Obesity: Mouse Study

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Drug Spurs Neuron Growth in Mice with Chronic Spinal Cord Injury

Giannina Descalzi

Giannina Descalzi Studies the Factors Underlying Chronic Pain

A black and brown ant stands over various sizes of whitish purple, oval shaped larvae and yellow, oblong eggs

A Single Transcription Factor Changes Ants to Queens

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Enhancers: Conserved in Activity, Not in Sequence

Eight Proteins Turn Mouse Stem Cells into Egglike Cells

Genetic Reprogramming Restores Vision in Mice: Study

Image of the Day: Tomato Domestication

oct4 yamanaka factor oskm ips ipsc induced pluripotent stem cell

Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed

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Image of the Day: Switch Gears

Image of the Day: Kaleidoscope

Reprogrammed Müller Glia Restore Vision in Mice

Image of the Day: Cooking Up Neurons

Colorblindness Study Reveals Unexpected Way to Make Blood Vessels

Image of the Day: Gene Expression

Paused RNA Polymerase Quashes New Initiation of Transcription

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

An illustration of mustard-colored mitochondria against a dark blue background.

Mitochondrial DNA: A Maternal Legacy That Helps Trace the Past and Diagnose the Future

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A Man Who Survived Hundreds of Snakebites Helped Scientists Develop a Potent Antivenom

Photo of a woman submerged in icy water with her head and clasped hands above water.

What are the Risks and Benefits of a Cold Plunge?

Multimedia

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
Exploring the Gut-Lung Axis in Health and Disease

Exploring the Gut-Lung Axis in Health and Disease

May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

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Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

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Characterizing Immune Memory to COVID-19 Vaccination

Characterizing Immune Memory to COVID-19 Vaccination

10X Genomics
Optimize PCR assays with true linear temperature gradients

Applied Biosystems™ VeriFlex™ System: True Temperature Control for PCR Protocols

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Products

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Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

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Agilent BioTek Cytation C10 Confocal Imaging Reader

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Sapio Sciences Introduces Biorepository Management Solution