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A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Methylation in Young Brains May Be Key to Obesity: Mouse Study

Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.

Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.

transcription factors
white mouse sitting down
Drug Spurs Neuron Growth in Mice with Chronic Spinal Cord Injury
Natalia Mesa, PhD | Sep 27, 2022 | 4 min read
A protein duo increases transcription of growth-related genes to enhance axon regeneration and boost plasticity, a study finds—but fails to improve mobility.
Giannina Descalzi
Giannina Descalzi Studies the Factors Underlying Chronic Pain
Natalia Mesa, PhD | May 16, 2022 | 3 min read
The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.
A black and brown ant stands over various sizes of whitish purple, oval shaped larvae and yellow, oblong eggs
A Single Transcription Factor Changes Ants to Queens
Abby Olena, PhD | Nov 5, 2021 | 3 min read
The transcription factor can also drive the opposite transition depending on which hormone activates it, according to a new study.
Conceptual image of gene expression in DNA
Enhancers: Conserved in Activity, Not in Sequence
Jack J. Lee | Nov 1, 2021 | 8 min read
Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Ashley Yeager | Dec 16, 2020 | 3 min read
The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  
Genetic Reprogramming Restores Vision in Mice: Study
Max Kozlov | Dec 6, 2020 | 5 min read
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020 | 1 min read
Scientists identify a transcription factor that plays a key role in increased fruit size.
oct4 yamanaka factor oskm ips ipsc induced pluripotent stem cell
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Emma Yasinski | Nov 8, 2019 | 3 min read
Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
Caught on Camera
The Scientist Staff | Oct 1, 2018 | 2 min read
Selected Images of the Day from the-scientist.com
Image of the Day: Switch Gears
Sukanya Charuchandra | Sep 10, 2018 | 1 min read
A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.
Image of the Day: Kaleidoscope
Sukanya Charuchandra | Aug 27, 2018 | 1 min read
A single transcription factor regulates a harlequin ladybird’s colors.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Image of the Day: Cooking Up Neurons
The Scientist Staff and The Scientist Staff | May 11, 2018 | 1 min read
Using different combinations of transcription factors, researchers create a diverse array of neurons from mouse skin cells.
Colorblindness Study Reveals Unexpected Way to Make Blood Vessels
Ashley Yeager | May 1, 2018 | 3 min read
Researchers stumbled across the connection while searching for ways to reduce vision problems in people with achromatopsia.
Image of the Day: Gene Expression
The Scientist Staff and The Scientist Staff | Apr 9, 2018 | 1 min read
A new algorithm scrutinizes the most hard-to-read segments of the genome.
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017 | 2 min read
Pauses may help cells fine-tune gene expression.
Bacterial Protein Acts as Prion in Yeast and E. coli
Jef Akst | Jan 16, 2017 | 2 min read
Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.
Synthetic Sensors
Ruth Williams | Dec 1, 2016 | 3 min read
Engineered circuits detect endogenous transcription factors to drive cellular outputs.
Infographic: How to Build a Synthetic Sensor
Ruth Williams | Nov 30, 2016 | 1 min read
Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.
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