TB over Time

Eighteenth-century DNA sequences yield insights into the history of tuberculosis infections.

Written byJef Akst
| 4 min read

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MUMMY DEAREST: The mummified remains of Terézia Hausmann, whose body was recovered from the Dominican Church in Vác, Hungary.HUNGARIAN NATURAL HISTORY MUSEUM

In 1997, when the field of paleomicrobiology was just emerging, University College London microbiologists Helen Donoghue and Mark Spigelman attended a conference in Hungary focused on the evolution of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). A few years earlier, Spigelman and PhD student Eshetu Lemma had published the first paper on ancient M. tuberculosis DNA, examining centuries-old samples using PCR (Int J Osteoarchaeol, 3:137-43, 1993). At the conference, Spigelman and Donoghue presented work they’d done to recover M. tuberculosis DNA from much-more-recent human skeletal remains, collected as part of a forensic case dating to the mid-20th century.

In the audience was Ildikó Pap, head of the anthropology department at the Hungarian Natural History Museum, who’d come to the conference to speak about a ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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