The Cellular Hallmarks of Consciousness

Recording from single neurons of epilepsy patients, neuroscientists show that both the strength and timing of neuronal firing are important to consciously perceive a visual object.

Written byAnna Azvolinsky
| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

FLICKR, REIGH LEBLANCTo define human consciousness at the neuronal level is among the most difficult of tasks for neuroscience. Still, researchers have made inroads, most recently by sinking electrodes deep with the brains of epilepsy patients and recording the activity of single neurons as the awake patients described whether they observed an image flashed before them.

Previous work had found that the stronger the individual neuron activity, the more likely it is to be associated with conscious perception. In this latest study, published today (September 21) in Current Biology, researchers from the University of Bonn Medical Center in Germany find a second factor—timing—that appears important to the brain’s conscious awareness. Firing of single neurons within the medial temporal lobe (MTL), which is important for long-term memory, was weaker and delayed when human subjects were not aware of seeing an image compared to when they reported seeing one.

“[The authors] contribute a major piece of the puzzle of human consciousness with a set of data that is very impressive,” says Rafael Malach, a neurobiologist who studies the human brain at the Weizmann ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • head shot of blond woman wearing glasses

    Anna Azvolinsky received a PhD in molecular biology in November 2008 from Princeton University. Her graduate research focused on a genome-wide analyses of genomic integrity and DNA replication. She did a one-year post-doctoral fellowship at Memorial Sloan Kettering Cancer Center in New York City and then left academia to pursue science writing. She has been a freelance science writer since 2012, based in New York City.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH