An Olfaction Odyssey

Thanks to a book, a war, and a big green caterpillar, John Hildebrand found himself mapping the exquisite and surprising wiring of the insect olfactory system.

Written byMegan Scudellari
| 9 min read

Register for free to listen to this article
Listen with Speechify
0:00
9:00
Share

JOHN G. HILDEBRAND
Regents Professor
Department of Neuroscience
University of Arizona
Tucson, Arizona
COURTESY OF JOHN HILDEBRAND
It began with a fateful encounter with a praying mantis. In 1965, a young John Hildebrand, then a biochemistry PhD student at Rockefeller University in New York City, spent his evenings in the university library catching up on the latest publications (“You know—before there was an Internet,” he says).

One night, long after the sun had set and only a few people still milled around the library, Hildebrand was perusing the New Books shelf and noticed a slim volume with a vivid color photograph of a praying mantis on the cover. “I really liked praying mantises—as a kid I used to keep them as pets—so I picked up the book,” says Hildebrand. He settled into a large easy chair and read the book from cover to cover.

“If I hadn’t liked praying mantises, I wouldn’t have picked up the book, and I don’t know that I would ever have found what I’ve loved doing ever since then.”

“When I put it back on the shelf, the little voice in my head said, ‘That’s it. ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

The Scientist Placeholder Image

Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

OGT logo

OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel